BGC0001035 - 1 region(s) - antiSMASH results

Identified secondary metabolite regions using strictness 'relaxed'

BGC0001035 (Glarea lozoyensis ATCC 20868)

Region	Type	From	To	Most similar known cluster		Similarity
Region 1	T1PKS,NRPS,betalactone	1	115,835	echinocandin B	NRP	92%

BGC0001035 - Region 1 - NRPS,T1PKS,betalactone

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Location: 1 - 115,835 nt. (total: 115,835 nt) Show pHMM detection rules used

Region on contig edge.

T1PKS: cds(PKS_AT and (PKS_KS or ene_KS or mod_KS or hyb_KS or itr_KS or tra_KS))
NRPS: cds(Condensation and (AMP-binding or A-OX))
betalactone: (HMGL-like and AMP-binding)

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core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

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Gene details

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MIBiG

NRPS/PKS domains

MIBiG comparison

KnownClusterBlast

NRPS/PKS modules

External annotation

Name		MIBiG
Version		3.0

Type		Subregion
Location		1 - 115,836
Label		BGC0001035

Detailed domain annotation

Selected features only

Show module domains

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001035.1	1.44	Other, Polyketide, NRP, , (, A, m, i, n, o, c, o, u, m, a, r, i, n, )	pneumocandin B0, pneumocandin A0	Glarea lozoyensis ATCC 20868
BGC0001858.1	0.66	Polyketide	alternapyrone B, alternapyrone C, alternapyrone D, alternapyrone E, alternapyrone F	Parastagonospora nodorum SN15
BGC0000046.1	0.56	Polyketide	depudecin	Alternaria brassicicola
BGC0001280.1	0.56	Polyketide	betaenone C, betaenone A	Phoma betae
BGC0001264.1	0.56	Polyketide	betaenone A, betaenone B, betaenone C	Phoma betae
BGC0001141.1	0.53	Polyketide	4-epi-15-epi-brefeldin A	Penicillium brefeldianum
BGC0001475.1	0.51	Polyketide	aspterric acid	Aspergillus terreus NIH2624
BGC0000003.1	0.49	Polyketide	AF-toxin	Alternaria alternata
BGC0000688.1	0.47	Terpene	copalyl diphosphate	Diaporthe amygdali
BGC0001909.1	0.46	Polyketide	strobilurin	Strobilurus tenacellus

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001035.1	0.98	Other, Polyketide, NRP, , (, A, m, i, n, o, c, o, u, m, a, r, i, n, )	pneumocandin B0, pneumocandin A0	Glarea lozoyensis ATCC 20868
BGC0001220.1	0.72	NRP	aculeacin A	Aspergillus japonicus
BGC0001858.1	0.66	Polyketide	alternapyrone B, alternapyrone C, alternapyrone D, alternapyrone E, alternapyrone F	Parastagonospora nodorum SN15
BGC0000046.1	0.66	Polyketide	depudecin	Alternaria brassicicola
BGC0001758.1	0.63	NRP	rhizomide A, rhizomide B, rhizomide C	Paraburkholderia rhizoxinica HKI 454
BGC0001131.1	0.63	NRP	ambactin	Xenorhabdus miraniensis
BGC0001261.1	0.62	NRP	AM-toxin	Alternaria alternata
BGC0001135.1	0.62	NRP	bicornutin A1, bicornutin A2	Xenorhabdus budapestensis
BGC0001844.1	0.62	NRP	holrhizin	Paraburkholderia rhizoxinica HKI 454
BGC0001141.1	0.62	Polyketide	4-epi-15-epi-brefeldin A	Penicillium brefeldianum

Similar known gene clusters

Module view

Legend

NRPS/PKS products

NRPS/PKS monomers

Predicted core structure(s)

For candidate cluster 1, location 20469 - 103446:

Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:: (Me-pk) + (X - X - X - X - X - X)

Direct lookup in NORINE database: strict or relaxed

For candidate cluster 2, location 20469 - 68499:

Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:: (Me-pk) + (X - X - X - X - X - X)

Direct lookup in NORINE database: strict or relaxed

For candidate cluster 3, location 30153 - 91843:

Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:: (Me-pk) + (X - X - X - X - X - X)

Direct lookup in NORINE database: strict or relaxed

Link to NORINE database query form

NRPS/PKS monomer predictions

GLAREA_10034

PKS_AT (602..906): pk

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 75.0%; Propionyl-CoA: 62.5%; 2-Methylbutyryl-CoA: 62.5%

minowa: Methylmalonyl-CoA

Prediction, score:

Methylmalonyl-CoA: 83.2
Methoxymalonyl-CoA: 77.0
Malonyl-CoA: 56.6
Ethylmalonyl-CoA: 46.5
Propionyl-CoA: 46.1
Benzoyl-CoA: 37.2
Isobutyryl-CoA: 37.0
2-Methylbutyryl-CoA: 36.3
trans-1,2-CPDA: 26.4
3-Methylbutyryl-CoA: 26.4
fatty_acid: 25.9
CHC-CoA: 25.5
inactive: 7.4
Acetyl-CoA: 6.0

GLAREA_10035

Search NORINE for peptide: strict or relaxed

AMP-binding (674..1052): X

NRPSPredictor2: hydrophobic-aliphatic

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic
Large clusters prediction:: N/A
Small clusters prediction:: N/A
Single AA prediction:: N/A

Stachelhaus prediction details:

Stachelhaus sequence:: dvceassivk
Nearest Stachelhaus code:: N, A
Stachelhaus code match:: 0% (weak)

AMP-binding (1757..2154): X

NRPSPredictor2: hydrophilic

SVM prediction details:

Predicted physicochemical class:: hydrophilic
Large clusters prediction:: N/A
Small clusters prediction:: N/A
Single AA prediction:: N/A

Stachelhaus prediction details:

Stachelhaus sequence:: daqtavaihk
Nearest Stachelhaus code:: N, A
Stachelhaus code match:: 0% (weak)

AMP-binding (2848..3245): X

NRPSPredictor2: hydrophobic-aliphatic

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic
Large clusters prediction:: N/A
Small clusters prediction:: N/A
Single AA prediction:: N/A

Stachelhaus prediction details:

Stachelhaus sequence:: dvssattvck
Nearest Stachelhaus code:: N, A
Stachelhaus code match:: 0% (weak)

AMP-binding (3919..4320): X

NRPSPredictor2: hydrophilic

SVM prediction details:

Predicted physicochemical class:: hydrophilic
Large clusters prediction:: N/A
Small clusters prediction:: N/A
Single AA prediction:: N/A

Stachelhaus prediction details:

Stachelhaus sequence:: dgeavgcifk
Nearest Stachelhaus code:: N, A
Stachelhaus code match:: 0% (weak)

AMP-binding (5012..5414): X

NRPSPredictor2: hydrophilic

SVM prediction details:

Predicted physicochemical class:: hydrophilic
Large clusters prediction:: N/A
Small clusters prediction:: N/A
Single AA prediction:: N/A

Stachelhaus prediction details:

Stachelhaus sequence:: daqniasink
Nearest Stachelhaus code:: N, A
Stachelhaus code match:: 0% (weak)

AMP-binding (6110..6507): X

NRPSPredictor2: hydrophobic-aliphatic

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic
Large clusters prediction:: N/A
Small clusters prediction:: N/A
Single AA prediction:: N/A

Stachelhaus prediction details:

Stachelhaus sequence:: dntmitamsk
Nearest Stachelhaus code:: N, A
Stachelhaus code match:: 0% (weak)

GLAREA_10043

Search NORINE for peptide: strict or relaxed

AMP-binding (39..463): X

NRPSPredictor2: (unknown)

SVM prediction details:

Predicted physicochemical class:: N/A
Large clusters prediction:: N/A
Small clusters prediction:: N/A
Single AA prediction:: N/A

Stachelhaus prediction details:

Stachelhaus sequence:: aylyiggvck
Nearest Stachelhaus code:: N, A
Stachelhaus code match:: 0% (weak)