BGC0001178 - 1 region(s) - antiSMASH results

Identified secondary metabolite regions using strictness 'relaxed'

BGC0001178 (Actinoplanes sp. ATCC 53533)

Region	Type	From	To	Most similar known cluster		Similarity
Region 1	NRPS,T3PKS	1	80,908	teicoplanin	NRP	63%

BGC0001178 - Region 1 - NRPS,T3PKS

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Location: 1 - 80,908 nt. (total: 80,908 nt) Show pHMM detection rules used

Region on contig edge.

NRPS: cds(Condensation and (AMP-binding or A-OX))
T3PKS: (Chal_sti_synt_C or Chal_sti_synt_N)

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core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

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TTA codons

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Gene details

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MIBiG

NRPS/PKS domains

MIBiG comparison

KnownClusterBlast

NRPS/PKS modules

External annotation

Name		MIBiG
Version		3.0

Type		Subregion
Location		1 - 80,909
Label		BGC0001178

Detailed domain annotation

Selected features only

Show module domains

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001178.1	0.79	NRP	UK-68,597	Actinoplanes sp. ATCC 53533
BGC0001366.1	0.42	Polyketide	BE-24566B, zunyimycin A	Streptomyces sp. FJS31-2
BGC0000426.1	0.37	NRP	sevadicin	Paenibacillus larvae
BGC0000351.1	0.36	NRP	exochelin	Mycolicibacterium smegmatis
BGC0000375.1	0.34	NRP	indigoidine	Streptomyces chromofuscus
BGC0000427.1	0.34	NRP	shinorine, 4-deoxygadusol, mycosporine glycine	Trichormus variabilis ATCC 29413
BGC0001479.1	0.34	NRP	anabaenopeptin NZ857, nostamide A	Nostoc punctiforme PCC 73102
BGC0000389.1	0.34	NRP	massetolide A	Pseudomonas fluorescens SS101
BGC0000837.1	0.33	Other	APE Vf	Aliivibrio fischeri ES114
BGC0001647.1	0.33	Polyketide	lagunapyrone A, lagunapyrone B, lagunapyrone C	Streptomyces sp. MP131-18

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001178.1	0.89	NRP	UK-68,597	Actinoplanes sp. ATCC 53533
BGC0000426.1	0.70	NRP	sevadicin	Paenibacillus larvae
BGC0000351.1	0.69	NRP	exochelin	Mycolicibacterium smegmatis
BGC0000375.1	0.68	NRP	indigoidine	Streptomyces chromofuscus
BGC0000902.1	0.67	Other	flaviolin	Saccharopolyspora erythraea NRRL 2338
BGC0000285.1	0.67	Polyketide, Saccharide	flaviolin rhamnoside, 3,3'-diflaviolin, flaviolin	Saccharopolyspora erythraea
BGC0000427.1	0.67	NRP	shinorine, 4-deoxygadusol, mycosporine glycine	Trichormus variabilis ATCC 29413
BGC0001479.1	0.67	NRP	anabaenopeptin NZ857, nostamide A	Nostoc punctiforme PCC 73102
BGC0000389.1	0.67	NRP	massetolide A	Pseudomonas fluorescens SS101
BGC0001310.1	0.67	Terpene	naringenin	Streptomyces clavuligerus ATCC 27064

Similar known gene clusters

Module view

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NRPS/PKS products

NRPS/PKS monomers

Predicted core structure(s)

For candidate cluster 1, location 0 - 80908:

Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:: (hpg - D-tyr) + (D-X) + (D-hpg - D-hpg - bht) + (dhpg)

Direct lookup in NORINE database: strict or relaxed

For candidate cluster 2, location 0 - 56972:

Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:: (hpg - D-tyr) + (D-X) + (D-hpg - D-hpg - bht) + (dhpg)

Direct lookup in NORINE database: strict or relaxed

Link to NORINE database query form

NRPS/PKS monomer predictions

AGS77307.1

Search NORINE for peptide: strict or relaxed

AMP-binding (15..402): hpg

NRPSPredictor2: hpg

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic
Large clusters prediction:: ser, thr, dhpg, hpg
Small clusters prediction:: dhpg, hpg
Single AA prediction:: hpg

Stachelhaus prediction details:

Stachelhaus sequence:: DAFHLGLLCK
Nearest Stachelhaus code:: hpg
Stachelhaus code match:: 100% (strong)

AMP-binding (1037..1423): tyr

NRPSPredictor2: tyr

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aromatic
Large clusters prediction:: phe, trp, phg, tyr, bht
Small clusters prediction:: tyr, bht
Single AA prediction:: tyr

Stachelhaus prediction details:

Stachelhaus sequence:: DASTVAAVCK
Nearest Stachelhaus code:: tyr
Stachelhaus code match:: 100% (strong)

AGS77308.1

Search NORINE for peptide: strict or relaxed

AMP-binding (466..854): X

NRPSPredictor2: (unknown)

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic
Large clusters prediction:: ser, thr, dhpg, hpg
Small clusters prediction:: dhpg, hpg
Single AA prediction:: dhpg

Stachelhaus prediction details:

Stachelhaus sequence:: DAYNAGsLCK
Nearest Stachelhaus code:: dpg
Stachelhaus code match:: 90% (moderate)

AGS77309.1

Search NORINE for peptide: strict or relaxed

AMP-binding (461..856): hpg

NRPSPredictor2: hpg

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic
Large clusters prediction:: ser, thr, dhpg, hpg
Small clusters prediction:: dhpg, hpg
Single AA prediction:: hpg

Stachelhaus prediction details:

Stachelhaus sequence:: DIFHLGLLCK
Nearest Stachelhaus code:: hpg
Stachelhaus code match:: 100% (strong)

AMP-binding (1960..2352): hpg

NRPSPredictor2: hpg

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic
Large clusters prediction:: ser, thr, dhpg, hpg
Small clusters prediction:: dhpg, hpg
Single AA prediction:: hpg

Stachelhaus prediction details:

Stachelhaus sequence:: DAVHLGLLCK
Nearest Stachelhaus code:: hpg
Stachelhaus code match:: 100% (strong)

AMP-binding (3475..3861): bht

NRPSPredictor2: bht

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aromatic
Large clusters prediction:: phe, trp, phg, tyr, bht
Small clusters prediction:: tyr, bht
Single AA prediction:: bht

Stachelhaus prediction details:

Stachelhaus sequence:: DASTIAGVCK
Nearest Stachelhaus code:: bht
Stachelhaus code match:: 100% (strong)

AGS77310.1

Search NORINE for peptide: strict or relaxed

AMP-binding (472..870): dhpg

NRPSPredictor2: dhpg

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic
Large clusters prediction:: ser, thr, dhpg, hpg
Small clusters prediction:: dhpg, hpg
Single AA prediction:: dhpg

Stachelhaus prediction details:

Stachelhaus sequence:: DPYHGGTLCK
Nearest Stachelhaus code:: dhpg
Stachelhaus code match:: 100% (strong)