BGC0000330 - 1 region(s) - antiSMASH results

Identified secondary metabolite regions using strictness 'relaxed'

BGC0000330 (Cupriavidus necator H16)

Region	Type	From	To	Most similar known cluster		Similarity
Region 1	NRPS	1	36,362	crochelin A	NRP + Polyketide	23%

BGC0000330 - Region 1 - NRPS

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Location: 1 - 36,362 nt. (total: 36,362 nt) Show pHMM detection rules used

Region on contig edge.

NRPS: cds(Condensation and (AMP-binding or A-OX))

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core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

TTA codons

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Gene details

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MIBiG

NRPS/PKS domains

MIBiG comparison

KnownClusterBlast

NRPS/PKS modules

External annotation

Name		MIBiG
Version		3.0

Type		Subregion
Location		1 - 36,363
Label		BGC0000330

Detailed domain annotation

Selected features only

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Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000330.1	0.93	NRP	cupriachelin	Cupriavidus necator H16
BGC0000465.1	0.33	NRP	xenortide A, xenortide B, xenortide C, xenortide D	Xenorhabdus nematophila ATCC 19061
BGC0000389.1	0.33	NRP	massetolide A	Pseudomonas fluorescens SS101
BGC0000426.1	0.33	NRP	sevadicin	Paenibacillus larvae
BGC0001434.1	0.33	NRP	nematophin	Xenorhabdus budapestensis
BGC0001698.1	0.33	NRP	nevaltophin A, nevaltophin B, nevaltophin C, nevaltophin D	Xenorhabdus budapestensis
BGC0001135.1	0.32	NRP	bicornutin A1, bicornutin A2	Xenorhabdus budapestensis
BGC0001629.1	0.31	NRP	Jessenipeptin	Pseudomonas sp. QS1027
BGC0001833.1	0.31	NRP	icosalide A, icosalide B	Burkholderia gladioli
BGC0002071.1	0.31	NRP	Virginiafactin	Pseudomonas sp. QS1027

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000330.1	0.98	NRP	cupriachelin	Cupriavidus necator H16
BGC0000465.1	0.66	NRP	xenortide A, xenortide B, xenortide C, xenortide D	Xenorhabdus nematophila ATCC 19061
BGC0000389.1	0.66	NRP	massetolide A	Pseudomonas fluorescens SS101
BGC0000426.1	0.66	NRP	sevadicin	Paenibacillus larvae
BGC0001434.1	0.66	NRP	nematophin	Xenorhabdus budapestensis
BGC0001698.1	0.66	NRP	nevaltophin A, nevaltophin B, nevaltophin C, nevaltophin D	Xenorhabdus budapestensis
BGC0001135.1	0.65	NRP	bicornutin A1, bicornutin A2	Xenorhabdus budapestensis
BGC0001629.1	0.65	NRP	Jessenipeptin	Pseudomonas sp. QS1027
BGC0001833.1	0.65	NRP	icosalide A, icosalide B	Burkholderia gladioli
BGC0002071.1	0.65	NRP	Virginiafactin	Pseudomonas sp. QS1027

Similar known gene clusters

Module view

Legend

NRPS/PKS products

NRPS/PKS monomers

Predicted core structure(s)

For candidate cluster 1, location 0 - 36362:

Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:: (asp - X) + (asp) + (D-X) + (gly)

Direct lookup in NORINE database: strict or relaxed

Link to NORINE database query form

NRPS/PKS monomer predictions

H16_B1683

Search NORINE for peptide: strict or relaxed

AMP-binding (480..882): gly

NRPSPredictor2: gly

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic
Large clusters prediction:: gly, ala, val, leu, ile, abu, iva
Small clusters prediction:: gly, ala
Single AA prediction:: gly

Stachelhaus prediction details:

Stachelhaus sequence:: DILQLGVvWK
Nearest Stachelhaus code:: gly
Stachelhaus code match:: 90% (moderate)

H16_B1685

Search NORINE for peptide: strict or relaxed

AMP-binding (513..915): X

NRPSPredictor2: (unknown)

SVM prediction details:

NOTE: outside applicability domain

Predicted physicochemical class:: hydrophilic
Large clusters prediction:: asp, asn, glu, gln, aad
Small clusters prediction:: N/A
Single AA prediction:: N/A

Stachelhaus prediction details:

Stachelhaus sequence:: DgegSGgVtK
Nearest Stachelhaus code:: glu
Stachelhaus code match:: 50% (weak)

H16_B1686

Search NORINE for peptide: strict or relaxed

AMP-binding (434..823): asp

NRPSPredictor2: asp

SVM prediction details:

Predicted physicochemical class:: hydrophilic
Large clusters prediction:: asp, asn, glu, gln, aad
Small clusters prediction:: asp, asn
Single AA prediction:: asp

Stachelhaus prediction details:

Stachelhaus sequence:: DLTKiGHIGK
Nearest Stachelhaus code:: asp
Stachelhaus code match:: 90% (moderate)

H16_B1687

Search NORINE for peptide: strict or relaxed

AMP-binding (512..910): asp

NRPSPredictor2: asp

SVM prediction details:

NOTE: outside applicability domain

Predicted physicochemical class:: hydrophilic
Large clusters prediction:: asp, asn, glu, gln, aad
Small clusters prediction:: asp, asn
Single AA prediction:: asp

Stachelhaus prediction details:

Stachelhaus sequence:: DLTKVGHVGK
Nearest Stachelhaus code:: asp
Stachelhaus code match:: 100% (strong)

AMP-binding (1667..2069): X

NRPSPredictor2: hydrophilic

SVM prediction details:

Predicted physicochemical class:: hydrophilic
Large clusters prediction:: N/A
Small clusters prediction:: N/A
Single AA prediction:: N/A

Stachelhaus prediction details:

Stachelhaus sequence:: DiWeLtadDK
Nearest Stachelhaus code:: ser
Stachelhaus code match:: 50% (weak)