BGC0000394 - 1 region(s) - antiSMASH results

Identified secondary metabolite regions using strictness 'relaxed'

BGC0000394 (Streptomyces lusitanus)

Region	Type	From	To	Most similar known cluster		Similarity
Region 1	NRPS,PKS-like	1	51,977	quinocarcin	NRP	37%

BGC0000394 - Region 1 - NRPS,PKS-like

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Location: 1 - 51,977 nt. (total: 51,977 nt) Show pHMM detection rules used

Region on contig edge.

NRPS: cds(Condensation and (AMP-binding or A-OX))
PKS-like: (t2pks2 or ksIII)

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core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

TTA codons

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Gene details

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MIBiG

NRPS/PKS domains

MIBiG comparison

KnownClusterBlast

NRPS/PKS modules

External annotation

Name		MIBiG
Version		3.0

Type		Subregion
Location		1 - 51,978
Label		BGC0000394

Detailed domain annotation

Selected features only

Show module domains

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000394.1	1.48	NRP	naphthyridinomycin	Streptomyces lusitanus
BGC0001399.1	0.64	NRP	fellutamide B	Aspergillus nidulans FGSC A4
BGC0001345.1	0.59	NRP	myxochelin A, myxochelin B	Stigmatella aurantiaca Sg a15
BGC0000389.1	0.59	NRP	massetolide A	Pseudomonas fluorescens SS101
BGC0002071.1	0.56	NRP	Virginiafactin	Pseudomonas sp. QS1027
BGC0000457.1	0.55	NRP	vicibactin	Rhizobium etli CFN 42
BGC0001833.1	0.55	NRP	icosalide A, icosalide B	Burkholderia gladioli
BGC0001050.1	0.53	NRP, Polyketide	thalassospiramide A	Tistrella bauzanensis
BGC0001444.1	0.53	Other	caboxamycin	Streptomyces sp. NTK 937
BGC0000465.1	0.53	NRP	xenortide A, xenortide B, xenortide C, xenortide D	Xenorhabdus nematophila ATCC 19061

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000394.1	0.99	NRP	naphthyridinomycin	Streptomyces lusitanus
BGC0000457.1	0.67	NRP	vicibactin	Rhizobium etli CFN 42
BGC0001833.1	0.65	NRP	icosalide A, icosalide B	Burkholderia gladioli
BGC0001399.1	0.65	NRP	fellutamide B	Aspergillus nidulans FGSC A4
BGC0000389.1	0.65	NRP	massetolide A	Pseudomonas fluorescens SS101
BGC0001345.1	0.64	NRP	myxochelin A, myxochelin B	Stigmatella aurantiaca Sg a15
BGC0002071.1	0.63	NRP	Virginiafactin	Pseudomonas sp. QS1027
BGC0001135.1	0.63	NRP	bicornutin A1, bicornutin A2	Xenorhabdus budapestensis
BGC0001128.1	0.63	NRP	luminmide	Photorhabdus laumondii subsp. laumondii TTO1
BGC0001050.1	0.63	NRP, Polyketide	thalassospiramide A	Tistrella bauzanensis

Similar known gene clusters

Module view

Legend

NRPS/PKS products

NRPS/PKS monomers

Predicted core structure(s)

For candidate cluster 1, location 0 - 51977:

Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:: (ala - ala - ala) + (X)

Direct lookup in NORINE database: strict or relaxed

For candidate cluster 2, location 0 - 30118:

Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:: (X)

Direct lookup in NORINE database: strict or relaxed

Link to NORINE database query form

NRPS/PKS monomer predictions

AGD80616.1

Search NORINE for peptide: strict or relaxed

AMP-binding (378..769): X

NRPSPredictor2: (unknown)

SVM prediction details:

NOTE: outside applicability domain

Predicted physicochemical class:: hydrophilic
Large clusters prediction:: gly, ala, val, leu, ile, abu, iva
Small clusters prediction:: val, leu, ile, abu, iva
Single AA prediction:: N/A

Stachelhaus prediction details:

Stachelhaus sequence:: DggHaGdVwK
Nearest Stachelhaus code:: glu
Stachelhaus code match:: 50% (weak)

AGD80618.1

Search NORINE for peptide: strict or relaxed

AMP-binding (488..887): X

NRPSPredictor2: (unknown)

SVM prediction details:

NOTE: outside applicability domain

Predicted physicochemical class:: hydrophobic-aliphatic
Large clusters prediction:: gly, ala, val, leu, ile, abu, iva
Small clusters prediction:: gly, ala
Single AA prediction:: N/A

Stachelhaus prediction details:

Stachelhaus sequence:: DAgdVAeVwK
Nearest Stachelhaus code:: phe
Stachelhaus code match:: 60% (weak)

AGD80622.1

CAL_domain (167..474): pk

minowa: NH2

Prediction, score:

NH2: 114.8
Acetyl-CoA: 37.3
fatty_acid: 29.3
AHBA: 26.9
shikimic_acid: 17.0

AGD80623.1

Search NORINE for peptide: strict or relaxed

AMP-binding (487..850): ala

NRPSPredictor2: ala

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic
Large clusters prediction:: gly, ala, val, leu, ile, abu, iva
Small clusters prediction:: gly, ala
Single AA prediction:: ala

Stachelhaus prediction details:

Stachelhaus sequence:: DLFNNALTYK
Nearest Stachelhaus code:: ala
Stachelhaus code match:: 100% (strong)

AMP-binding (1515..1878): ala

NRPSPredictor2: ala

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic
Large clusters prediction:: gly, ala, val, leu, ile, abu, iva
Small clusters prediction:: gly, ala
Single AA prediction:: ala

Stachelhaus prediction details:

Stachelhaus sequence:: DLFNNALTYK
Nearest Stachelhaus code:: ala
Stachelhaus code match:: 100% (strong)

AMP-binding (2535..2898): ala

NRPSPredictor2: ala

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic
Large clusters prediction:: gly, ala, val, leu, ile, abu, iva
Small clusters prediction:: gly, ala
Single AA prediction:: ala

Stachelhaus prediction details:

Stachelhaus sequence:: DLFNNALTYK
Nearest Stachelhaus code:: ala
Stachelhaus code match:: 100% (strong)