BGC0000519 - 1 region(s) - antiSMASH results

Identified secondary metabolite regions using strictness 'relaxed'

BGC0000519 (Actinomadura namibiensis)

Region	Type	From	To	Most similar known cluster		Similarity
Region 1	lanthipeptide-class-iii	1	6,400	Ery-9 / Ery-6 / Ery-8 / Ery-7 / Ery-5 / Ery-4 / Ery-3	RiPP:Lanthipeptide	75%

BGC0000519 - Region 1 - lanthipeptide-class-iii

Download region GenBank file

Download region SVG

Location: 1 - 6,400 nt. (total: 6,400 nt) Show pHMM detection rules used

Region on contig edge.

lanthipeptide-class-iii: (micKC and not PKS_KS)

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

TTA codons

reset view

zoom to selection

Gene details

Select a gene to view the details available for it

MIBiG

MIBiG comparison

KnownClusterBlast

Lanthipeptides

External annotation

Name		MIBiG
Version		3.0

Type		Subregion
Location		1 - 6,401
Label		BGC0000519

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000519.1	1.00	RiPP	labyrinthopeptin A2, labyrinthopeptin A1, labyrinthopeptin A3	Actinomadura namibiensis
BGC0000563.1	0.31	RiPP	venezuelin	Streptomyces venezuelae ATCC 10712
BGC0000551.1	0.30	RiPP	SapB	Streptomyces coelicolor A3(2)
BGC0000501.1	0.27	RiPP	catenulipeptin	Catenulispora acidiphila DSM 44928
BGC0000496.1	0.24	RiPP	AmfS	Streptomyces griseus subsp. griseus NBRC 13350
BGC0001579.1	0.24	RiPP	duramycin	Streptomyces cinnamoneus
BGC0000554.1	0.21	RiPP	SRO15-3108	Streptomyces filamentosus NRRL 15998
BGC0000513.1	0.19	RiPP	Ery-9, Ery-6, Ery-8, Ery-7, Ery-5, Ery-4, Ery-3	Saccharopolyspora erythraea NRRL 2338
BGC0000553.1	0.17	RiPP	SRO15-2212	Streptomyces filamentosus NRRL 15998
BGC0001484.1	0.16	Other	2'-chloropentostatin, 2'-amino-2'-deoxyadenosine	Actinomadura sp. ATCC 39365

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000519.1	1.00	RiPP	labyrinthopeptin A2, labyrinthopeptin A1, labyrinthopeptin A3	Actinomadura namibiensis
BGC0000563.1	0.65	RiPP	venezuelin	Streptomyces venezuelae ATCC 10712
BGC0000551.1	0.63	RiPP	SapB	Streptomyces coelicolor A3(2)
BGC0000501.1	0.60	RiPP	catenulipeptin	Catenulispora acidiphila DSM 44928
BGC0000496.1	0.57	RiPP	AmfS	Streptomyces griseus subsp. griseus NBRC 13350
BGC0001579.1	0.57	RiPP	duramycin	Streptomyces cinnamoneus
BGC0000554.1	0.54	RiPP	SRO15-3108	Streptomyces filamentosus NRRL 15998
BGC0000513.1	0.51	RiPP	Ery-9, Ery-6, Ery-8, Ery-7, Ery-5, Ery-4, Ery-3	Saccharopolyspora erythraea NRRL 2338
BGC0000553.1	0.48	RiPP	SRO15-2212	Streptomyces filamentosus NRRL 15998
BGC0001484.1	0.47	Other	2'-chloropentostatin, 2'-amino-2'-deoxyadenosine	Actinomadura sp. ATCC 39365

Similar known gene clusters

Lanthipeptide predictions

Lanthipeptide(s) for labKC

labA1

Leader:

MASILELQDLEVERASSAAD

Core:

SNASVWECCSTGSWVPFTCC

Core with dehydrations:

DhaNADhaVWECysCysDhaDhbGDhaWVPFDhbCysCys

labA2

Leader:

MASILELQNLDVEHARGENR

Core:

SDWSLWECCSTGSLFACC

Core with dehydrations:

DhaDWDhaLWECysCysDhaDhbGDhaLFACysCys

Legend:

Dha: Didehydroalanine
Dhb: Didehydrobutyrine

Lanthipeptides

Core peptide predictions

labA1 - Class III

Cleavage pHMM score: 18.60

RODEO score: 0

Monoisotopic mass: 2057.8 Da

Molecular weight: 2059.3 Da

Number of bridges: 4

Alternative weights: (assuming N unmodified Ser/Thr residues); 2077.3 Da N = 1; 2095.3 Da N = 2

labA2 - Class III

Cleavage pHMM score: 26.00

RODEO score: 0

Monoisotopic mass: 1906.7 Da

Molecular weight: 1908.1 Da

Number of bridges: 4

Alternative weights: (assuming N unmodified Ser/Thr residues); 1926.2 Da N = 1