BGC0000534 - 1 region(s) - antiSMASH results

Identified secondary metabolite regions using strictness 'relaxed'

BGC0000534 (Streptococcus mutans)

Region	Type	From	To	Most similar known cluster		Similarity
Region 1	lanthipeptide-class-ii	1	6,359	macedocin	RiPP:Lanthipeptide	42%

BGC0000534 - Region 1 - lanthipeptide-class-ii

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Location: 1 - 6,359 nt. (total: 6,359 nt) Show pHMM detection rules used

Region on contig edge.

lanthipeptide-class-ii: cds(LANC_like and DUF4135)

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

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Gene details

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MIBiG

MIBiG comparison

KnownClusterBlast

Lanthipeptides

External annotation

Name		MIBiG
Version		3.0

Type		Subregion
Location		1 - 6,360
Label		BGC0000534

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000534.1	1.00	RiPP	mutacin K8	Streptococcus mutans
BGC0000526.1	0.34	RiPP	macedocin	Streptococcus macedonicus
BGC0001788.1	0.33	RiPP	suicin 65	Streptococcus suis
BGC0000532.1	0.32	RiPP	mutacin II	Streptococcus mutans
BGC0000557.1	0.30	RiPP	streptococcin A-FF22	Streptococcus pyogenes
BGC0000500.1	0.26	RiPP	carnolysin A1, carnolysin A2	Carnobacterium maltaromaticum
BGC0000516.1	0.24	RiPP	geobacillin II	Geobacillus thermodenitrificans
BGC0000539.1	0.23	RiPP	nukacin ISK-1	Staphylococcus warneri
BGC0000550.1	0.22	RiPP	salivaricin G32	Streptococcus salivarius
BGC0000499.1	0.21	RiPP	butyrivibriocin OR79	Butyrivibrio fibrisolvens

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000534.1	1.00	RiPP	mutacin K8	Streptococcus mutans
BGC0000526.1	0.67	RiPP	macedocin	Streptococcus macedonicus
BGC0001788.1	0.66	RiPP	suicin 65	Streptococcus suis
BGC0000532.1	0.66	RiPP	mutacin II	Streptococcus mutans
BGC0000557.1	0.63	RiPP	streptococcin A-FF22	Streptococcus pyogenes
BGC0000500.1	0.60	RiPP	carnolysin A1, carnolysin A2	Carnobacterium maltaromaticum
BGC0000516.1	0.58	RiPP	geobacillin II	Geobacillus thermodenitrificans
BGC0000539.1	0.56	RiPP	nukacin ISK-1	Staphylococcus warneri
BGC0000550.1	0.55	RiPP	salivaricin G32	Streptococcus salivarius
BGC0000499.1	0.54	RiPP	butyrivibriocin OR79	Butyrivibrio fibrisolvens

Similar known gene clusters

Lanthipeptide predictions

Lanthipeptide(s) for mukM

mukA1

Leader:

MKNTTNEMLELIQEVSLDELDQVIGG

mukA3

Leader:

MKQSNEMLELIQEVSLDELDQVIGG

Shared core:

MGKGAVGTISHECRYNSWAFLATCCS

Core with dehydrations:

MGKGAVGDhbIDhaHECysRYNDhaWAFLADhbCysCysDha

mukA2

Leader:

MKQSDEMLELIQEVSLDELDQVIGG

Core:

AGNGVIRTITQGCRMPNNMQVLFTC

Core with dehydrations:

AGNGVIRDhbIDhbQGCysRMPNNMQVLFDhbCys

mukA_

Leader:

MKKGTQLYLEALEALQEIKVEELDTFIGG

Core:

GGRASNTISSDCRWNSLQAIFSCC

Core with dehydrations:

GGRADhaNDhbIDhaDhaDCysRWNDhaLQAIFDhaCysCys

Legend:

Dha: Didehydroalanine
Dhb: Didehydrobutyrine

Lanthipeptides

Core peptide predictions

mukA1 - Class II

Cleavage pHMM score: 4.60

RODEO score: 0

Monoisotopic mass: 2701.2 Da

Molecular weight: 2703.1 Da

Number of bridges: 3

Alternative weights: (assuming N unmodified Ser/Thr residues); 2721.1 Da N = 1; 2739.1 Da N = 2

mukA2 - Class II

Cleavage pHMM score: 4.60

RODEO score: 0

Monoisotopic mass: 2669.3 Da

Molecular weight: 2671.1 Da

Number of bridges: 2

Alternative weights: (assuming N unmodified Ser/Thr residues); 2689.2 Da N = 1

mukA3 - Class II

Cleavage pHMM score: 4.60

RODEO score: 0

Monoisotopic mass: 2701.2 Da

Molecular weight: 2703.1 Da

Number of bridges: 3

Alternative weights: (assuming N unmodified Ser/Thr residues); 2721.1 Da N = 1; 2739.1 Da N = 2

mukA_ - Class II

Cleavage pHMM score: 1.70

RODEO score: 0

Monoisotopic mass: 2467.1 Da

Molecular weight: 2468.7 Da

Number of bridges: 3

Alternative weights: (assuming N unmodified Ser/Thr residues); 2486.7 Da N = 1; 2504.8 Da N = 2; 2522.8 Da N = 3