BGC0000949 - 1 region(s) - antiSMASH results

Identified secondary metabolite regions using strictness 'relaxed'

BGC0000949 (Streptomyces griseus)

Region	Type	From	To	Most similar known cluster		Similarity
Region 1	blactam,NRPS	1	65,257	A-503083 A / A-503083 B / A-503083 E / A-503083 F	NRP	40%

BGC0000949 - Region 1 - NRPS,blactam

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Location: 1 - 65,257 nt. (total: 65,257 nt) Show pHMM detection rules used

Region on contig edge.

blactam: (BLS or CAS or tabtoxin)
NRPS: cds(Condensation and (AMP-binding or A-OX))

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core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

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TTA codons

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Gene details

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MIBiG

NRPS/PKS domains

MIBiG comparison

KnownClusterBlast

NRPS/PKS modules

External annotation

Name		MIBiG
Version		3.0

Type		Subregion
Location		1 - 65,258
Label		BGC0000949

Detailed domain annotation

Selected features only

Show module domains

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000949.1	1.12	NRP	A-500359 A, A-500359 B	Streptomyces griseus
BGC0000288.1	0.46	NRP	A-503083 A, A-503083 B, A-503083 E, A-503083 F	Streptomyces sp. SANK 62799
BGC0001191.1	0.43	Other	A-102395	Amycolatopsis sp. SANK 60206
BGC0000025.1	0.32	Polyketide	avermectin	Streptomyces avermitilis
BGC0001399.1	0.31	NRP	fellutamide B	Aspergillus nidulans FGSC A4
BGC0000246.1	0.27	Polyketide	mithramycin	Streptomyces argillaceus
BGC0001251.1	0.26	NRP	epichloenin A	Epichloe festucae
BGC0001250.1	0.26	NRP	epichloenin A	Epichloe festucae
BGC0001151.1	0.25	Other, , (, N, o, n, -, N, R, P, , b, e, t, a, -, l, a, c, t, a, m, )	valclavam, (-)-2-(2-hydroxyethyl)clavam	Streptomyces antibioticus
BGC0000825.1	0.25	Alkaloid	staurosporine	Streptomyces sp. TP-A0274

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000949.1	0.99	NRP	A-500359 A, A-500359 B	Streptomyces griseus
BGC0000288.1	0.69	NRP	A-503083 A, A-503083 B, A-503083 E, A-503083 F	Streptomyces sp. SANK 62799
BGC0001399.1	0.64	NRP	fellutamide B	Aspergillus nidulans FGSC A4
BGC0002071.1	0.61	NRP	Virginiafactin	Pseudomonas sp. QS1027
BGC0000389.1	0.60	NRP	massetolide A	Pseudomonas fluorescens SS101
BGC0001251.1	0.60	NRP	epichloenin A	Epichloe festucae
BGC0001250.1	0.60	NRP	epichloenin A	Epichloe festucae
BGC0001609.1	0.58	NRP	gliovirin	Trichoderma virens Gv29-8
BGC0001517.1	0.58	NRP	asperphenamate	Aspergillus terreus NIH2624
BGC0000843.1	0.57	Other, , (, N, o, n, -, N, R, P, , b, e, t, a, -, l, a, c, t, a, m, )	alanylclavam, 2-hydroxymethylclavam, 2-formyloxymethylclavam, clavam-2-carboxylate	Streptomyces clavuligerus ATCC 27064

Similar known gene clusters

Module view

Legend

NRPS/PKS products

NRPS/PKS monomers

Predicted core structure(s)

For candidate cluster 1, location 7863 - 65257:

Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:: (X)

Direct lookup in NORINE database: strict or relaxed

For candidate cluster 3, location 22328 - 65257:

Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:: (X)

Direct lookup in NORINE database: strict or relaxed

Link to NORINE database query form

NRPS/PKS monomer predictions

BAI23334.1

Search NORINE for peptide: strict or relaxed

AMP-binding (500..891): X

NRPSPredictor2: (unknown)

SVM prediction details:

Predicted physicochemical class:: N/A
Large clusters prediction:: N/A
Small clusters prediction:: N/A
Single AA prediction:: N/A

Stachelhaus prediction details:

Stachelhaus sequence:: DvfeSGgVGK
Nearest Stachelhaus code:: glu
Stachelhaus code match:: 60% (weak)