BGC0001013 - 1 region(s) - antiSMASH results

Identified secondary metabolite regions using strictness 'relaxed'

BGC0001013 (Streptomyces sp)

Region	Type	From	To	Most similar known cluster		Similarity
Region 1	NRPS,T1PKS	1	116,856	meridamycin	NRP + Polyketide	31%

BGC0001013 - Region 1 - NRPS,T1PKS

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Location: 1 - 116,856 nt. (total: 116,856 nt) Show pHMM detection rules used

Region on contig edge.

NRPS: cds(Condensation and (AMP-binding or A-OX))
T1PKS: cds(PKS_AT and (PKS_KS or ene_KS or mod_KS or hyb_KS or itr_KS or tra_KS))

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core biosynthetic genes

additional biosynthetic genes

transport-related genes

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TTA codons

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Gene details

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MIBiG

NRPS/PKS domains

MIBiG comparison

KnownClusterBlast

NRPS/PKS modules

External annotation

Name		MIBiG
Version		3.0

Type		Subregion
Location		1 - 116,857
Label		BGC0001013

Detailed domain annotation

Selected features only

Show module domains

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001013.1	0.96	NRP, Polyketide	meridamycin	Streptomyces sp.
BGC0001050.1	0.67	NRP, Polyketide	thalassospiramide A	Tistrella bauzanensis
BGC0001012.1	0.60	NRP, Polyketide	meridamycin	Streptomyces violaceusniger
BGC0000342.1	0.55	NRP	enniatin	Fusarium equiseti
BGC0002057.1	0.54	Polyketide	pateamine	Kiritimatiellaeota bacterium
BGC0000041.1	0.52	Polyketide	oronofacic acid	Pseudomonas syringae
BGC0001132.1	0.50	NRP	xenotetrapeptide	Xenorhabdus nematophila ATCC 19061
BGC0000313.1	0.49	NRP	beauvericin	Beauveria bassiana
BGC0001844.1	0.49	NRP	holrhizin	Paraburkholderia rhizoxinica HKI 454
BGC0000457.1	0.49	NRP	vicibactin	Rhizobium etli CFN 42

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001013.1	0.89	NRP, Polyketide	meridamycin	Streptomyces sp.
BGC0001012.1	0.74	NRP, Polyketide	meridamycin	Streptomyces violaceusniger
BGC0000041.1	0.67	Polyketide	oronofacic acid	Pseudomonas syringae
BGC0001050.1	0.67	NRP, Polyketide	thalassospiramide A	Tistrella bauzanensis
BGC0001909.1	0.64	Polyketide	strobilurin	Strobilurus tenacellus
BGC0001164.1	0.64	Polyketide	1-heptadecene	Cyanothece sp. PCC 7822
BGC0000067.1	0.64	Polyketide	geldanamycin	Streptomyces hygroscopicus subsp. duamyceticus
BGC0001901.1	0.63	Polyketide	tricholignan A	Trichoderma harzianum
BGC0001854.1	0.62	Polyketide	tricholignan A	Trichoderma harzianum
BGC0000057.1	0.62	Polyketide	F9775A, F9775B, orsellinic acid	Aspergillus nidulans FGSC A4

Similar known gene clusters

Module view

Legend

NRPS/PKS products

NRPS/PKS monomers

Predicted core structure(s)

For candidate cluster 1, location 1637 - 116856:

Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:: (pip) + (mal - pk - Me-ccmal - ohmal) + (pk - pk - pk - pk) + (ohmal - ohmal - pk - ohmal - ohmal) + (pk - ccmal)

Direct lookup in NORINE database: strict or relaxed

For candidate cluster 2, location 1637 - 46311:

Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:: (pip) + (mal - pk - Me-ccmal - ohmal) + (pk - pk - pk - pk)

Direct lookup in NORINE database: strict or relaxed

For candidate cluster 3, location 6334 - 116856:

Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:: (pip) + (mal - pk - Me-ccmal - ohmal) + (pk - pk - pk - pk) + (ohmal - ohmal - pk - ohmal - ohmal) + (pk - ccmal)

Direct lookup in NORINE database: strict or relaxed

Link to NORINE database query form

NRPS/PKS monomer predictions

ctg1_orf19

Search NORINE for peptide: strict or relaxed

AMP-binding (487..903): pip

NRPSPredictor2: pip

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic
Large clusters prediction:: pro, pip
Small clusters prediction:: pro
Single AA prediction:: pro

Stachelhaus prediction details:

Stachelhaus sequence:: DIQFSAHVVK
Nearest Stachelhaus code:: pip
Stachelhaus code match:: 100% (strong)

ctg1_orf20

PKS_AT (565..863): mal

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 95.8%; inactive: 79.2%; 2-Rhyd-Malonyl-CoA: 54.2%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 190.8
inactive: 94.4
Methoxymalonyl-CoA: 69.9
Methylmalonyl-CoA: 51.4
Propionyl-CoA: 26.6
Isobutyryl-CoA: 25.4
Ethylmalonyl-CoA: 21.5
Acetyl-CoA: 20.3
fatty_acid: 16.1
2-Methylbutyryl-CoA: 13.8
Benzoyl-CoA: 10.0
CHC-CoA: 9.4
trans-1,2-CPDA: 5.1
3-Methylbutyryl-CoA: 0.0

PKS_AT (1574..1859): pk

ATSignature: Methylmalonyl-CoA

Top 3 matches:: Methylmalonyl-CoA: 100.0%; Methoxymalonyl-CoA: 95.8%; Ethylmalonyl-CoA: 91.7%

minowa: Ethylmalonyl-CoA

Prediction, score:

Ethylmalonyl-CoA: 220.0
Methylmalonyl-CoA: 213.8
Methoxymalonyl-CoA: 171.9
2-Methylbutyryl-CoA: 144.0
trans-1,2-CPDA: 139.9
CHC-CoA: 128.0
Propionyl-CoA: 113.7
Malonyl-CoA: 91.7
Isobutyryl-CoA: 79.3
Benzoyl-CoA: 73.8
Acetyl-CoA: 51.7
fatty_acid: 40.7
inactive: 23.2
3-Methylbutyryl-CoA: 19.9

PKS_AT (3027..3312): mmal

ATSignature: Methylmalonyl-CoA

Top 3 matches:: Methylmalonyl-CoA: 100.0%; Methoxymalonyl-CoA: 95.8%; Ethylmalonyl-CoA: 91.7%

minowa: Methylmalonyl-CoA

Prediction, score:

Methylmalonyl-CoA: 209.8
Ethylmalonyl-CoA: 209.1
Methoxymalonyl-CoA: 166.8
2-Methylbutyryl-CoA: 145.0
trans-1,2-CPDA: 143.6
Propionyl-CoA: 121.2
CHC-CoA: 118.7
Malonyl-CoA: 87.8
Isobutyryl-CoA: 73.0
Benzoyl-CoA: 67.4
Acetyl-CoA: 53.4
fatty_acid: 41.2
inactive: 22.6
3-Methylbutyryl-CoA: 10.9

PKS_AT (4702..4975): mal

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 95.8%; inactive: 79.2%; Methylmalonyl-CoA: 54.2%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 212.4
inactive: 116.1
Methoxymalonyl-CoA: 61.2
Methylmalonyl-CoA: 49.5
Isobutyryl-CoA: 37.6
Propionyl-CoA: 33.5
Ethylmalonyl-CoA: 28.5
Benzoyl-CoA: 28.3
Acetyl-CoA: 18.1
2-Methylbutyryl-CoA: 15.5
fatty_acid: 14.7
CHC-CoA: 11.7
trans-1,2-CPDA: 10.9
3-Methylbutyryl-CoA: 0.0

ctg1_orf21

PKS_AT (558..856): pk

ATSignature: Methoxymalonyl-CoA

Top 3 matches:: Methoxymalonyl-CoA: 87.5%; Ethylmalonyl-CoA: 83.3%; Methylmalonyl-CoA: 79.2%

minowa: Ethylmalonyl-CoA

Prediction, score:

Ethylmalonyl-CoA: 186.1
Methylmalonyl-CoA: 179.0
Methoxymalonyl-CoA: 152.5
2-Methylbutyryl-CoA: 119.3
trans-1,2-CPDA: 115.7
Propionyl-CoA: 95.4
CHC-CoA: 89.3
Malonyl-CoA: 81.7
Isobutyryl-CoA: 59.3
fatty_acid: 40.2
Benzoyl-CoA: 33.8
Acetyl-CoA: 29.6
inactive: 20.4
3-Methylbutyryl-CoA: 16.0

PKS_AT (2268..2554): pk

ATSignature: Methylmalonyl-CoA

Top 3 matches:: Methylmalonyl-CoA: 100.0%; Methoxymalonyl-CoA: 95.8%; Ethylmalonyl-CoA: 91.7%

minowa: Ethylmalonyl-CoA

Prediction, score:

Ethylmalonyl-CoA: 214.2
Methylmalonyl-CoA: 208.4
Methoxymalonyl-CoA: 168.0
2-Methylbutyryl-CoA: 148.0
trans-1,2-CPDA: 140.9
CHC-CoA: 114.4
Propionyl-CoA: 113.2
Malonyl-CoA: 88.2
Isobutyryl-CoA: 63.8
Benzoyl-CoA: 55.2
Acetyl-CoA: 40.4
fatty_acid: 40.2
3-Methylbutyryl-CoA: 31.1
inactive: 21.9

PKS_AT (3808..4093): pk

ATSignature: Methylmalonyl-CoA

Top 3 matches:: Methylmalonyl-CoA: 100.0%; Methoxymalonyl-CoA: 95.8%; Ethylmalonyl-CoA: 91.7%

minowa: Ethylmalonyl-CoA

Prediction, score:

Ethylmalonyl-CoA: 211.5
Methylmalonyl-CoA: 210.3
Methoxymalonyl-CoA: 167.2
2-Methylbutyryl-CoA: 148.1
trans-1,2-CPDA: 144.0
CHC-CoA: 121.1
Propionyl-CoA: 120.3
Malonyl-CoA: 89.1
Isobutyryl-CoA: 76.7
Benzoyl-CoA: 70.2
Acetyl-CoA: 56.1
fatty_acid: 41.1
inactive: 25.4
3-Methylbutyryl-CoA: 10.9

PKS_AT (5843..6128): pk

ATSignature: Methylmalonyl-CoA

Top 3 matches:: Methylmalonyl-CoA: 100.0%; Methoxymalonyl-CoA: 95.8%; Ethylmalonyl-CoA: 91.7%

minowa: Ethylmalonyl-CoA

Prediction, score:

Ethylmalonyl-CoA: 214.1
Methylmalonyl-CoA: 209.3
Methoxymalonyl-CoA: 167.0
trans-1,2-CPDA: 142.1
2-Methylbutyryl-CoA: 136.4
CHC-CoA: 124.0
Propionyl-CoA: 117.0
Malonyl-CoA: 89.0
Isobutyryl-CoA: 72.4
Benzoyl-CoA: 62.3
Acetyl-CoA: 46.7
fatty_acid: 33.3
inactive: 21.2
3-Methylbutyryl-CoA: 11.6

ctg1_orf22

PKS_AT (571..844): mal

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 95.8%; inactive: 79.2%; Methylmalonyl-CoA: 54.2%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 211.4
inactive: 114.8
Methoxymalonyl-CoA: 58.0
Methylmalonyl-CoA: 49.7
Isobutyryl-CoA: 36.1
Propionyl-CoA: 32.8
Ethylmalonyl-CoA: 30.7
Benzoyl-CoA: 25.9
Acetyl-CoA: 19.4
fatty_acid: 18.9
2-Methylbutyryl-CoA: 14.0
trans-1,2-CPDA: 10.2
CHC-CoA: 8.9
3-Methylbutyryl-CoA: 0.0

PKS_AT (2024..2297): mal

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 91.7%; inactive: 75.0%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 210.7
inactive: 113.5
Methoxymalonyl-CoA: 63.3
Methylmalonyl-CoA: 52.5
Isobutyryl-CoA: 38.9
Propionyl-CoA: 35.5
Ethylmalonyl-CoA: 29.4
Benzoyl-CoA: 26.4
Acetyl-CoA: 19.5
2-Methylbutyryl-CoA: 16.2
fatty_acid: 14.7
trans-1,2-CPDA: 12.5
CHC-CoA: 12.4
3-Methylbutyryl-CoA: 0.0

PKS_AT (3477..3764): pk

ATSignature: Methylmalonyl-CoA

Top 3 matches:: Methylmalonyl-CoA: 100.0%; Methoxymalonyl-CoA: 95.8%; Ethylmalonyl-CoA: 91.7%

minowa: Ethylmalonyl-CoA

Prediction, score:

Ethylmalonyl-CoA: 220.4
Methylmalonyl-CoA: 215.2
Methoxymalonyl-CoA: 171.6
2-Methylbutyryl-CoA: 146.9
trans-1,2-CPDA: 145.4
CHC-CoA: 124.6
Propionyl-CoA: 117.3
Malonyl-CoA: 89.4
Isobutyryl-CoA: 72.8
Benzoyl-CoA: 63.4
Acetyl-CoA: 48.4
fatty_acid: 40.7
inactive: 17.5
3-Methylbutyryl-CoA: 15.6

PKS_AT (5004..5277): mal

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 95.8%; inactive: 79.2%; Methylmalonyl-CoA: 54.2%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 210.5
inactive: 112.2
Methoxymalonyl-CoA: 60.5
Methylmalonyl-CoA: 52.8
Propionyl-CoA: 36.1
Isobutyryl-CoA: 35.1
Ethylmalonyl-CoA: 32.6
Acetyl-CoA: 23.4
Benzoyl-CoA: 20.5
2-Methylbutyryl-CoA: 18.5
fatty_acid: 15.2
trans-1,2-CPDA: 12.1
CHC-CoA: 11.9
3-Methylbutyryl-CoA: 0.0

PKS_AT (6458..6731): mal

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 95.8%; inactive: 79.2%; Methylmalonyl-CoA: 54.2%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 209.9
inactive: 109.3
Methoxymalonyl-CoA: 62.3
Methylmalonyl-CoA: 47.6
Propionyl-CoA: 30.7
Isobutyryl-CoA: 26.2
Benzoyl-CoA: 26.0
Ethylmalonyl-CoA: 25.1
Acetyl-CoA: 20.1
2-Methylbutyryl-CoA: 14.0
fatty_acid: 11.6
CHC-CoA: 10.6
trans-1,2-CPDA: 9.9
3-Methylbutyryl-CoA: 0.0

ctg1_orf23

PKS_AT (10..229): pk

ATSignature: Methylmalonyl-CoA

Top 3 matches:: Methylmalonyl-CoA: 75.0%; Methoxymalonyl-CoA: 70.8%; Malonyl-CoA: 70.8%

minowa: Ethylmalonyl-CoA

Prediction, score:

Ethylmalonyl-CoA: 174.5
Methylmalonyl-CoA: 169.4
Methoxymalonyl-CoA: 133.6
2-Methylbutyryl-CoA: 113.2
trans-1,2-CPDA: 103.2
CHC-CoA: 91.0
Propionyl-CoA: 83.1
Malonyl-CoA: 67.5
Isobutyryl-CoA: 48.4
Benzoyl-CoA: 48.0
Acetyl-CoA: 47.1
fatty_acid: 35.4
3-Methylbutyryl-CoA: 14.2
inactive: 13.0

PKS_AT (2086..2375): mal

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 83.3%; inactive: 70.8%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 192.5
inactive: 94.1
Methoxymalonyl-CoA: 66.1
Methylmalonyl-CoA: 60.2
Propionyl-CoA: 38.4
Ethylmalonyl-CoA: 29.8
Isobutyryl-CoA: 27.4
Acetyl-CoA: 22.7
CHC-CoA: 16.4
fatty_acid: 13.8
2-Methylbutyryl-CoA: 12.6
trans-1,2-CPDA: 10.8
Benzoyl-CoA: 10.5
3-Methylbutyryl-CoA: 0.0