BGC0001056 - 1 region(s) - antiSMASH results

Identified secondary metabolite regions using strictness 'relaxed'

BGC0001056 (Serratia plymuthica RVH1)

Region	Type	From	To	Most similar known cluster		Similarity
Region 1	PUFA,hglE-KS,NRPS,T1PKS	1	55,138	fabclavine Ia	NRP + Polyketide	85%

BGC0001056 - Region 1 - NRPS,PUFA,T1PKS,hglE-KS

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Location: 1 - 55,138 nt. (total: 55,138 nt) Show pHMM detection rules used

Region on contig edge.

PUFA: PUFA_KS
hglE-KS: (hglE or hglD)
NRPS: cds(Condensation and (AMP-binding or A-OX))
T1PKS: cds(PKS_AT and (PKS_KS or ene_KS or mod_KS or hyb_KS or itr_KS or tra_KS))

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core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

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Gene details

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MIBiG

NRPS/PKS domains

MIBiG comparison

KnownClusterBlast

NRPS/PKS modules

External annotation

Name		MIBiG
Version		3.0

Type		Subregion
Location		1 - 55,139
Label		BGC0001056

Detailed domain annotation

Selected features only

Show module domains

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001056.1	2.43	NRP, Polyketide	zeamine, zeamine I, zeamine II, prezeamine, prezeamine I	Serratia plymuthica RVH1
BGC0001872.1	1.24	Polyketide	fabclavine-polyamine	Xenorhabdus bovienii SS-2004
BGC0000979.1	1.16	NRP, Polyketide	cylindrospermopsin	Aphanizomenon sp. 10E9
BGC0000980.1	1.16	NRP, Polyketide	cylindrospermopsin	Aphanizomenon sp. 22D11
BGC0001130.1	1.11	NRP, Polyketide	fabclavine Ia	Xenorhabdus budapestensis
BGC0000161.1	1.00	Polyketide	isoterrein	Aspergillus terreus NIH2624
BGC0000013.1	1.00	Polyketide	alternariol	Aspergillus nidulans FGSC A4
BGC0000389.1	0.97	NRP	massetolide A	Pseudomonas fluorescens SS101
BGC0002071.1	0.97	NRP	Virginiafactin	Pseudomonas sp. QS1027
BGC0000284.1	0.96	Polyketide	phenolic lipids	Azotobacter vinelandii DJ

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001056.1	0.98	NRP, Polyketide	zeamine, zeamine I, zeamine II, prezeamine, prezeamine I	Serratia plymuthica RVH1
BGC0001130.1	0.75	NRP, Polyketide	fabclavine Ia	Xenorhabdus budapestensis
BGC0001872.1	0.71	Polyketide	fabclavine-polyamine	Xenorhabdus bovienii SS-2004
BGC0002071.1	0.71	NRP	Virginiafactin	Pseudomonas sp. QS1027
BGC0000389.1	0.71	NRP	massetolide A	Pseudomonas fluorescens SS101
BGC0000979.1	0.69	NRP, Polyketide	cylindrospermopsin	Aphanizomenon sp. 10E9
BGC0000980.1	0.69	NRP, Polyketide	cylindrospermopsin	Aphanizomenon sp. 22D11
BGC0001135.1	0.67	NRP	bicornutin A1, bicornutin A2	Xenorhabdus budapestensis
BGC0001023.1	0.66	NRP, Polyketide	myxochromide S1	Stigmatella aurantiaca
BGC0000457.1	0.65	NRP	vicibactin	Rhizobium etli CFN 42

Similar known gene clusters

Module view

Legend

NRPS/PKS products

NRPS/PKS monomers

Predicted core structure(s)

For candidate cluster 1, location 0 - 55138:

Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:: (mal) + (X - phe - D-asn - asn) + (thr - val) + (ohmal)

Direct lookup in NORINE database: strict or relaxed

For candidate cluster 3, location 0 - 35194:

Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:: (mal) + (X - phe - D-asn - asn)

Direct lookup in NORINE database: strict or relaxed

For candidate cluster 4, location 5459 - 55138:

Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:: (mal) + (X - phe - D-asn - asn) + (thr - val) + (ohmal)

Direct lookup in NORINE database: strict or relaxed

Link to NORINE database query form

NRPS/PKS monomer predictions

zmn10

PKS_AT (593..893): mal

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 75.0%; inactive: 62.5%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 71.3
Methoxymalonyl-CoA: 37.9
Methylmalonyl-CoA: 36.2
CHC-CoA: 23.2
Isobutyryl-CoA: 19.2
fatty_acid: 18.7
Propionyl-CoA: 17.5
Benzoyl-CoA: 15.3
inactive: 14.1
Ethylmalonyl-CoA: 10.1
trans-1,2-CPDA: 0.0
Acetyl-CoA: 0.0
3-Methylbutyryl-CoA: 0.0
2-Methylbutyryl-CoA: 0.0

zmn16

Search NORINE for peptide: strict or relaxed

AMP-binding (6..404): X

NRPSPredictor2: hydrophobic-aliphatic

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic
Large clusters prediction:: N/A
Small clusters prediction:: N/A
Single AA prediction:: N/A

Stachelhaus prediction details:

Stachelhaus sequence:: DprHLaLLaK
Nearest Stachelhaus code:: hpg
Stachelhaus code match:: 60% (weak)

AMP-binding (1054..1448): phe

NRPSPredictor2: phe

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aromatic
Large clusters prediction:: phe, trp, phg, tyr, bht
Small clusters prediction:: phe, trp
Single AA prediction:: phe

Stachelhaus prediction details:

Stachelhaus sequence:: DtWTIAsVsK
Nearest Stachelhaus code:: phe
Stachelhaus code match:: 70% (weak)

AMP-binding (2091..2493): asn

NRPSPredictor2: asn

SVM prediction details:

Predicted physicochemical class:: hydrophilic
Large clusters prediction:: asp, asn, glu, gln, aad
Small clusters prediction:: asp, asn
Single AA prediction:: asn

Stachelhaus prediction details:

Stachelhaus sequence:: DATKVGEVGK
Nearest Stachelhaus code:: asn
Stachelhaus code match:: 100% (strong)

AMP-binding (3578..3972): asn

NRPSPredictor2: asn

SVM prediction details:

Predicted physicochemical class:: hydrophilic
Large clusters prediction:: asp, asn, glu, gln, aad
Small clusters prediction:: asp, asn
Single AA prediction:: asn

Stachelhaus prediction details:

Stachelhaus sequence:: DATKVGEVGK
Nearest Stachelhaus code:: asn
Stachelhaus code match:: 100% (strong)

zmn17

Search NORINE for peptide: strict or relaxed

AMP-binding (475..892): thr

NRPSPredictor2: thr

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic
Large clusters prediction:: ser, thr, dhpg, hpg
Small clusters prediction:: thr
Single AA prediction:: thr

Stachelhaus prediction details:

Stachelhaus sequence:: DFWNIGMVHK
Nearest Stachelhaus code:: thr
Stachelhaus code match:: 100% (strong)

AMP-binding (1573..1969): val

NRPSPredictor2: val

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic
Large clusters prediction:: gly, ala, val, leu, ile, abu, iva
Small clusters prediction:: val, leu, ile, abu, iva
Single AA prediction:: val

Stachelhaus prediction details:

Stachelhaus sequence:: DALfIGGTFK
Nearest Stachelhaus code:: val
Stachelhaus code match:: 90% (moderate)

zmn18

PKS_AT (545..830): mal

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 87.5%; inactive: 79.2%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 158.6
inactive: 102.1
Methoxymalonyl-CoA: 51.3
Methylmalonyl-CoA: 44.6
Propionyl-CoA: 33.0
Isobutyryl-CoA: 29.9
Ethylmalonyl-CoA: 19.3
2-Methylbutyryl-CoA: 12.4
CHC-CoA: 9.7
fatty_acid: 9.3
Benzoyl-CoA: 8.9
trans-1,2-CPDA: 0.0
Acetyl-CoA: 0.0
3-Methylbutyryl-CoA: 0.0