BGC0001311 - 1 region(s) - antiSMASH results

Identified secondary metabolite regions using strictness 'relaxed'

BGC0001311 (Ruminococcus flavefaciens FD-1)

Region	Type	From	To	Most similar known cluster		Similarity
Region 1	lanthipeptide-class-ii	1	15,410

BGC0001311 - Region 1 - lanthipeptide-class-ii

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Location: 1 - 15,410 nt. (total: 15,410 nt) Show pHMM detection rules used

Region on contig edge.

lanthipeptide-class-ii: cds(LANC_like and DUF4135)

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

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Gene details

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MIBiG

MIBiG comparison

KnownClusterBlast

Lanthipeptides

External annotation

Name		MIBiG
Version		3.0

Type		Subregion
Location		1 - 15,411
Label		BGC0001311

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001311.1	0.77	RiPP	flavecins	Ruminococcus flavefaciens FD-1
BGC0001229.1	0.34	RiPP	SBI-06990 A1, SBI-06989 A2	Streptomyces bingchenggensis BCW-1
BGC0001579.1	0.33	RiPP	duramycin	Streptomyces cinnamoneus
BGC0000525.1	0.32	RiPP	lichenicidin VK21 A1, lichenicidin VK21 A2	Bacillus licheniformis
BGC0000554.1	0.28	RiPP	SRO15-3108	Streptomyces filamentosus NRRL 15998
BGC0000500.1	0.28	RiPP	carnolysin A1, carnolysin A2	Carnobacterium maltaromaticum
BGC0000504.1	0.27	RiPP	cytolysin ClyLl, cytolysin ClyLs	Plasmid pAD1
BGC0000528.1	0.25	RiPP	michiganin A	Clavibacter michiganensis subsp. michiganensis NCPPB 382
BGC0001787.1	0.24	RiPP	suicin 3908	Streptococcus suis
BGC0000498.1	0.24	RiPP	bovicin HJ50	Streptococcus equinus

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001311.1	0.92	RiPP	flavecins	Ruminococcus flavefaciens FD-1
BGC0001229.1	0.67	RiPP	SBI-06990 A1, SBI-06989 A2	Streptomyces bingchenggensis BCW-1
BGC0001579.1	0.67	RiPP	duramycin	Streptomyces cinnamoneus
BGC0000525.1	0.65	RiPP	lichenicidin VK21 A1, lichenicidin VK21 A2	Bacillus licheniformis
BGC0000554.1	0.62	RiPP	SRO15-3108	Streptomyces filamentosus NRRL 15998
BGC0000500.1	0.61	RiPP	carnolysin A1, carnolysin A2	Carnobacterium maltaromaticum
BGC0000504.1	0.61	RiPP	cytolysin ClyLl, cytolysin ClyLs	Plasmid pAD1
BGC0000528.1	0.58	RiPP	michiganin A	Clavibacter michiganensis subsp. michiganensis NCPPB 382
BGC0001787.1	0.57	RiPP	suicin 3908	Streptococcus suis
BGC0000498.1	0.57	RiPP	bovicin HJ50	Streptococcus equinus

Similar known gene clusters

No matches found.

Lanthipeptide predictions

Lanthipeptide(s) for RUMFLAFD1_RS0111205

RUMFLAFD1_RS0111140

Leader:

MSEKNMEKAGVVKADELDEMIDETTGGA

Core:

STVNTVGIHTTYLISKGLQNCPLKPTTILPILPRK

Core with dehydrations:

DhaDhbVNDhbVGIHDhbDhbYLIDhaKGLQNCysPLKPDhbDhbILPILPRK

RUMFLAFD1_RS0111145

Leader:

MDNNTKLQKLYEQLAATGSEKELDAMLDENMAGA

Core:

GSPLTVTITGLIVAATTGFDWCPTGACTYSCRV

Core with dehydrations:

GDhaPLDhbVDhbIDhbGLIVAADhbDhbGFDWCysPDhbGACysDhbYDhaCysRV

RUMFLAFD1_RS0111150

Leader:

MENKFDMEKFKKLAAVVSEDELDTLLDETTVGA

Core:

GSSNDCADLILKITGVVVSATSKFDWCPTGACTTSCRF

Core with dehydrations:

GDhaDhaNDCysADLILKIDhbGVVVDhaADhbDhaKFDWCysPDhbGACysDhbDhbDhaCysRF

RUMFLAFD1_RS0111155

Leader:

MDNNTEKFNELAAIADESELNEMLDENITGA

Core:

GSTIQCVNTTIGTILSVVFDCCPTSACTPPCRF

Core with dehydrations:

GDhaDhbIQCysVNDhbDhbIGDhbILDhaVVFDCysCysPDhbDhaACysDhbPPCysRF

RUMFLAFD1_RS0111160

Leader:

MNNKEFNMEQFKKLAAVVSEDELDEMLDENVTGA

Core:

ASSIPCAKVVVKVTTVVVAATTGFDWCPTGACTTSCRF

Core with dehydrations:

ADhaDhaIPCysAKVVVKVDhbDhbVVVAADhbDhbGFDWCysPDhbGACysDhbDhbDhaCysRF

RUMFLAFD1_RS0111165

Leader:

MEKMNNIAGITPENELDEMFDDSVVGA

Core:

VGYTTYWGILPLVTKNPQICPVSENTVKCRLL

Core with dehydrations:

VGYDhbDhbYWGILPLVDhbKNPQICysPVDhaENDhbVKCysRLL

RUMFLAFD1_RS0111170

Leader:

MNNNNFDMEKFKKLAAIVSEGEIDEMLDETTVGA

Core:

ASTLPCAEVVVTVTGIIVKATTGFDWCPTGACTHSCRF

Core with dehydrations:

ADhaDhbLPCysAEVVVDhbVDhbGIIVKADhbDhbGFDWCysPDhbGACysDhbHDhaCysRF

RUMFLAFD1_RS0111185

Leader:

MNKNPIYRSEEEAKNIACGNVAAELDENSQALDAINGA

Core:

GWKQTIACTIAQGTLGCLVSYGLGNGGYCCTYTVECSKTCNK

Core with dehydrations:

GWKQDhbIACysDhbIAQGDhbLGCysLVDhaYGLGNGGYCysCysDhbYDhbVECysDhaKDhbCysNK

RUMFLAFD1_RS0111195

Leader:

MERYGHLAGVIPVDEIDDMFESNVIGG

Core:

TSSIDCVRLASNTPEGTVNLTVRIEFCPSAACTYSCRL

Core with dehydrations:

DhbDhaDhaIDCysVRLADhaNDhbPEGDhbVNLDhbVRIEFCysPDhaAACysDhbYDhaCysRL

allorf_14471_14638

Leader:

VYALMKPLRDRFSQRFLYLYKVKGA

Core:

CQAYPENAGHSQKSPVYSSTLTKMTFTPFL

Core with dehydrations:

CysQAYPENAGHDhaQKDhaPVYDhaDhaDhbLDhbKMDhbFDhbPFL

Lanthipeptide(s) for RUMFLAFD1_RS0111210

RUMFLAFD1_RS0111140

Leader:

MSEKNMEKAGVVKADELDEMIDETTGGA

Core:

STVNTVGIHTTYLISKGLQNCPLKPTTILPILPRK

Core with dehydrations:

DhaDhbVNDhbVGIHDhbDhbYLIDhaKGLQNCysPLKPDhbDhbILPILPRK

RUMFLAFD1_RS0111145

Leader:

MDNNTKLQKLYEQLAATGSEKELDAMLDENMAGA

Core:

GSPLTVTITGLIVAATTGFDWCPTGACTYSCRV

Core with dehydrations:

GDhaPLDhbVDhbIDhbGLIVAADhbDhbGFDWCysPDhbGACysDhbYDhaCysRV

RUMFLAFD1_RS0111150

Leader:

MENKFDMEKFKKLAAVVSEDELDTLLDETTVGA

Core:

GSSNDCADLILKITGVVVSATSKFDWCPTGACTTSCRF

Core with dehydrations:

GDhaDhaNDCysADLILKIDhbGVVVDhaADhbDhaKFDWCysPDhbGACysDhbDhbDhaCysRF

RUMFLAFD1_RS0111155

Leader:

MDNNTEKFNELAAIADESELNEMLDENITGA

Core:

GSTIQCVNTTIGTILSVVFDCCPTSACTPPCRF

Core with dehydrations:

GDhaDhbIQCysVNDhbDhbIGDhbILDhaVVFDCysCysPDhbDhaACysDhbPPCysRF

RUMFLAFD1_RS0111160

Leader:

MNNKEFNMEQFKKLAAVVSEDELDEMLDENVTGA

Core:

ASSIPCAKVVVKVTTVVVAATTGFDWCPTGACTTSCRF

Core with dehydrations:

ADhaDhaIPCysAKVVVKVDhbDhbVVVAADhbDhbGFDWCysPDhbGACysDhbDhbDhaCysRF

RUMFLAFD1_RS0111165

Leader:

MEKMNNIAGITPENELDEMFDDSVVGA

Core:

VGYTTYWGILPLVTKNPQICPVSENTVKCRLL

Core with dehydrations:

VGYDhbDhbYWGILPLVDhbKNPQICysPVDhaENDhbVKCysRLL

RUMFLAFD1_RS0111170

Leader:

MNNNNFDMEKFKKLAAIVSEGEIDEMLDETTVGA

Core:

ASTLPCAEVVVTVTGIIVKATTGFDWCPTGACTHSCRF

Core with dehydrations:

ADhaDhbLPCysAEVVVDhbVDhbGIIVKADhbDhbGFDWCysPDhbGACysDhbHDhaCysRF

RUMFLAFD1_RS0111185

Leader:

MNKNPIYRSEEEAKNIACGNVAAELDENSQALDAINGA

Core:

GWKQTIACTIAQGTLGCLVSYGLGNGGYCCTYTVECSKTCNK

Core with dehydrations:

GWKQDhbIACysDhbIAQGDhbLGCysLVDhaYGLGNGGYCysCysDhbYDhbVECysDhaKDhbCysNK

RUMFLAFD1_RS0111195

Leader:

MERYGHLAGVIPVDEIDDMFESNVIGG

Core:

TSSIDCVRLASNTPEGTVNLTVRIEFCPSAACTYSCRL

Core with dehydrations:

DhbDhaDhaIDCysVRLADhaNDhbPEGDhbVNLDhbVRIEFCysPDhaAACysDhbYDhaCysRL

allorf_14471_14638

Leader:

VYALMKPLRDRFSQRFLYLYKVKGA

Core:

CQAYPENAGHSQKSPVYSSTLTKMTFTPFL

Core with dehydrations:

CysQAYPENAGHDhaQKDhaPVYDhaDhaDhbLDhbKMDhbFDhbPFL

Legend:

Dha: Didehydroalanine
Dhb: Didehydrobutyrine

Lanthipeptides

Core peptide predictions

RUMFLAFD1_RS0111140 - Class II

Cleavage pHMM score: -4.20

RODEO score: 0

Monoisotopic mass: 3672.2 Da

Molecular weight: 3674.4 Da

Number of bridges: 1

Alternative weights: (assuming N unmodified Ser/Thr residues); 3692.4 Da N = 1; 3710.4 Da N = 2; 3728.4 Da N = 3; 3746.4 Da N = 4; 3764.5 Da N = 5; 3782.5 Da N = 6; 3800.5 Da N = 7

RUMFLAFD1_RS0111145 - Class II

Cleavage pHMM score: -0.40

RODEO score: 0

Monoisotopic mass: 3198.6 Da

Molecular weight: 3200.7 Da

Number of bridges: 3

Alternative weights: (assuming N unmodified Ser/Thr residues); 3218.7 Da N = 1; 3236.7 Da N = 2; 3254.7 Da N = 3; 3272.7 Da N = 4; 3290.8 Da N = 5; 3308.8 Da N = 6

RUMFLAFD1_RS0111150 - Class II

Cleavage pHMM score: -4.60

RODEO score: 0

Monoisotopic mass: 3772.8 Da

Molecular weight: 3775.3 Da

Number of bridges: 4

Alternative weights: (assuming N unmodified Ser/Thr residues); 3793.3 Da N = 1; 3811.3 Da N = 2; 3829.3 Da N = 3; 3847.4 Da N = 4; 3865.4 Da N = 5; 3883.4 Da N = 6

RUMFLAFD1_RS0111155 - Class II

Cleavage pHMM score: -2.30

RODEO score: 0

Monoisotopic mass: 3271.6 Da

Molecular weight: 3273.8 Da

Number of bridges: 5

Alternative weights: (assuming N unmodified Ser/Thr residues); 3291.8 Da N = 1; 3309.8 Da N = 2; 3327.9 Da N = 3; 3345.9 Da N = 4

RUMFLAFD1_RS0111160 - Class II

Cleavage pHMM score: -2.50

RODEO score: 0

Monoisotopic mass: 3695.9 Da

Molecular weight: 3698.3 Da

Number of bridges: 4

Alternative weights: (assuming N unmodified Ser/Thr residues); 3716.3 Da N = 1; 3734.4 Da N = 2; 3752.4 Da N = 3; 3770.4 Da N = 4; 3788.4 Da N = 5; 3806.4 Da N = 6

RUMFLAFD1_RS0111165 - Class II

Cleavage pHMM score: 0.70

RODEO score: 0

Monoisotopic mass: 3514.9 Da

Molecular weight: 3517.1 Da

Number of bridges: 2

Alternative weights: (assuming N unmodified Ser/Thr residues); 3535.2 Da N = 1; 3553.2 Da N = 2; 3571.2 Da N = 3

RUMFLAFD1_RS0111170 - Class II

Cleavage pHMM score: -4.60

RODEO score: 0

Monoisotopic mass: 3778.9 Da

Molecular weight: 3781.4 Da

Number of bridges: 4

Alternative weights: (assuming N unmodified Ser/Thr residues); 3799.4 Da N = 1; 3817.4 Da N = 2; 3835.4 Da N = 3; 3853.4 Da N = 4; 3871.5 Da N = 5

RUMFLAFD1_RS0111185 - Class II

Cleavage pHMM score: 1.00

RODEO score: 0

Monoisotopic mass: 4250.0 Da

Molecular weight: 4252.9 Da

Number of bridges: 6

Alternative weights: (assuming N unmodified Ser/Thr residues); 4270.9 Da N = 1; 4288.9 Da N = 2

RUMFLAFD1_RS0111195 - Class II

Cleavage pHMM score: -1.70

RODEO score: 0

Monoisotopic mass: 3896.9 Da

Molecular weight: 3899.4 Da

Number of bridges: 4

Alternative weights: (assuming N unmodified Ser/Thr residues); 3917.4 Da N = 1; 3935.5 Da N = 2; 3953.5 Da N = 3; 3971.5 Da N = 4; 3989.5 Da N = 5; 4007.5 Da N = 6

allorf_14471_14638 - Class II

Cleavage pHMM score: -6.30

RODEO score: 0

Monoisotopic mass: 3188.6 Da

Molecular weight: 3190.6 Da

Number of bridges: 1

Alternative weights: (assuming N unmodified Ser/Thr residues); 3208.6 Da N = 1; 3226.6 Da N = 2; 3244.6 Da N = 3; 3262.7 Da N = 4; 3280.7 Da N = 5; 3298.7 Da N = 6; 3316.7 Da N = 7

RUMFLAFD1_RS0111140 - Class II

Cleavage pHMM score: -4.20

RODEO score: 0

Monoisotopic mass: 3672.2 Da

Molecular weight: 3674.4 Da

Number of bridges: 1

Alternative weights: (assuming N unmodified Ser/Thr residues); 3692.4 Da N = 1; 3710.4 Da N = 2; 3728.4 Da N = 3; 3746.4 Da N = 4; 3764.5 Da N = 5; 3782.5 Da N = 6; 3800.5 Da N = 7

RUMFLAFD1_RS0111145 - Class II

Cleavage pHMM score: -0.40

RODEO score: 0

Monoisotopic mass: 3198.6 Da

Molecular weight: 3200.7 Da

Number of bridges: 3

Alternative weights: (assuming N unmodified Ser/Thr residues); 3218.7 Da N = 1; 3236.7 Da N = 2; 3254.7 Da N = 3; 3272.7 Da N = 4; 3290.8 Da N = 5; 3308.8 Da N = 6

RUMFLAFD1_RS0111150 - Class II

Cleavage pHMM score: -4.60

RODEO score: 0

Monoisotopic mass: 3772.8 Da

Molecular weight: 3775.3 Da

Number of bridges: 4

Alternative weights: (assuming N unmodified Ser/Thr residues); 3793.3 Da N = 1; 3811.3 Da N = 2; 3829.3 Da N = 3; 3847.4 Da N = 4; 3865.4 Da N = 5; 3883.4 Da N = 6

RUMFLAFD1_RS0111155 - Class II

Cleavage pHMM score: -2.30

RODEO score: 0

Monoisotopic mass: 3271.6 Da

Molecular weight: 3273.8 Da

Number of bridges: 5

Alternative weights: (assuming N unmodified Ser/Thr residues); 3291.8 Da N = 1; 3309.8 Da N = 2; 3327.9 Da N = 3; 3345.9 Da N = 4

RUMFLAFD1_RS0111160 - Class II

Cleavage pHMM score: -2.50

RODEO score: 0

Monoisotopic mass: 3695.9 Da

Molecular weight: 3698.3 Da

Number of bridges: 4

Alternative weights: (assuming N unmodified Ser/Thr residues); 3716.3 Da N = 1; 3734.4 Da N = 2; 3752.4 Da N = 3; 3770.4 Da N = 4; 3788.4 Da N = 5; 3806.4 Da N = 6

RUMFLAFD1_RS0111165 - Class II

Cleavage pHMM score: 0.70

RODEO score: 0

Monoisotopic mass: 3514.9 Da

Molecular weight: 3517.1 Da

Number of bridges: 2

Alternative weights: (assuming N unmodified Ser/Thr residues); 3535.2 Da N = 1; 3553.2 Da N = 2; 3571.2 Da N = 3

RUMFLAFD1_RS0111170 - Class II

Cleavage pHMM score: -4.60

RODEO score: 0

Monoisotopic mass: 3778.9 Da

Molecular weight: 3781.4 Da

Number of bridges: 4

Alternative weights: (assuming N unmodified Ser/Thr residues); 3799.4 Da N = 1; 3817.4 Da N = 2; 3835.4 Da N = 3; 3853.4 Da N = 4; 3871.5 Da N = 5

RUMFLAFD1_RS0111185 - Class II

Cleavage pHMM score: 1.00

RODEO score: 0

Monoisotopic mass: 4250.0 Da

Molecular weight: 4252.9 Da

Number of bridges: 6

Alternative weights: (assuming N unmodified Ser/Thr residues); 4270.9 Da N = 1; 4288.9 Da N = 2

RUMFLAFD1_RS0111195 - Class II

Cleavage pHMM score: -1.70

RODEO score: 0

Monoisotopic mass: 3896.9 Da

Molecular weight: 3899.4 Da

Number of bridges: 4

Alternative weights: (assuming N unmodified Ser/Thr residues); 3917.4 Da N = 1; 3935.5 Da N = 2; 3953.5 Da N = 3; 3971.5 Da N = 4; 3989.5 Da N = 5; 4007.5 Da N = 6

allorf_14471_14638 - Class II

Cleavage pHMM score: -6.30

RODEO score: 0

Monoisotopic mass: 3188.6 Da

Molecular weight: 3190.6 Da

Number of bridges: 1

Alternative weights: (assuming N unmodified Ser/Thr residues); 3208.6 Da N = 1; 3226.6 Da N = 2; 3244.6 Da N = 3; 3262.7 Da N = 4; 3280.7 Da N = 5; 3298.7 Da N = 6; 3316.7 Da N = 7