BGC0001393 - 1 region(s) - antiSMASH results

Identified secondary metabolite regions using strictness 'relaxed'

BGC0001393 (Staphylococcus lugdunensis N920143)

Region	Type	From	To	Most similar known cluster		Similarity
Region 1	NRPS,NRPS-like	1	30,784

BGC0001393 - Region 1 - NRPS,NRPS-like

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Location: 1 - 30,784 nt. (total: 30,784 nt) Show pHMM detection rules used

Region on contig edge.

NRPS: cds(Condensation and (AMP-binding or A-OX))
NRPS-like: cds((PP-binding or NAD_binding_4) and (AMP-binding or A-OX))

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core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

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Gene details

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MIBiG

NRPS/PKS domains

MIBiG comparison

KnownClusterBlast

NRPS/PKS modules

External annotation

Name		MIBiG
Version		3.0

Type		Subregion
Location		1 - 30,785
Label		BGC0001393

Detailed domain annotation

Selected features only

Show module domains

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001393.1	1.61	NRP	lugdunin	Staphylococcus lugdunensis N920143
BGC0000900.1	0.62	Other	ferrichrome	Aspergillus oryzae
BGC0000427.1	0.61	NRP	shinorine, 4-deoxygadusol, mycosporine glycine	Trichormus variabilis ATCC 29413
BGC0001871.1	0.59	NRP	L-2-amino-4-methoxy-trans-3-butenoic acid	Pseudomonas aeruginosa PAO1
BGC0001250.1	0.55	NRP	epichloenin A	Epichloe festucae
BGC0000901.1	0.50	Other	ferrichrome	Aspergillus niger
BGC0001132.1	0.48	NRP	xenotetrapeptide	Xenorhabdus nematophila ATCC 19061
BGC0001050.1	0.48	NRP, Polyketide	thalassospiramide A	Tistrella bauzanensis
BGC0001128.1	0.47	NRP	luminmide	Photorhabdus laumondii subsp. laumondii TTO1
BGC0001561.1	0.46	NRP	curacomycin	Streptomyces curacoi

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001393.1	0.99	NRP	lugdunin	Staphylococcus lugdunensis N920143
BGC0000900.1	0.64	Other	ferrichrome	Aspergillus oryzae
BGC0001871.1	0.64	NRP	L-2-amino-4-methoxy-trans-3-butenoic acid	Pseudomonas aeruginosa PAO1
BGC0000427.1	0.64	NRP	shinorine, 4-deoxygadusol, mycosporine glycine	Trichormus variabilis ATCC 29413
BGC0001250.1	0.64	NRP	epichloenin A	Epichloe festucae
BGC0002058.1	0.62	Other	Reutericyclin A, Reutericyclin B, Reutericyclin C, Reutericyclin D	Streptococcus mutans B04Sm5
BGC0000901.1	0.60	Other	ferrichrome	Aspergillus niger
BGC0000372.1	0.60	NRP	hexadehydroastechrome, terezine-D, astechrome	Aspergillus fumigatus Af293
BGC0001132.1	0.59	NRP	xenotetrapeptide	Xenorhabdus nematophila ATCC 19061
BGC0001050.1	0.59	NRP, Polyketide	thalassospiramide A	Tistrella bauzanensis

Similar known gene clusters

No matches found.

Module view

Legend

NRPS/PKS products

NRPS/PKS monomers

Predicted core structure(s)

For candidate cluster 1, location 0 - 30784:

Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:: (val - X) + (val) + (val) + (cys)

Direct lookup in NORINE database: strict or relaxed

For candidate cluster 2, location 6468 - 30784:

Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:: (val - X) + (val) + (val) + (cys)

Direct lookup in NORINE database: strict or relaxed

Link to NORINE database query form

NRPS/PKS monomer predictions

SLUG_08100

Search NORINE for peptide: strict or relaxed

AMP-binding (446..832): val

NRPSPredictor2: val

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic
Large clusters prediction:: gly, ala, val, leu, ile, abu, iva
Small clusters prediction:: val, leu, ile, abu, iva
Single AA prediction:: val

Stachelhaus prediction details:

Stachelhaus sequence:: DAFffGGTFK
Nearest Stachelhaus code:: val
Stachelhaus code match:: 80% (moderate)

AMP-binding (1844..2200): X

NRPSPredictor2: hydrophobic-aliphatic

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic
Large clusters prediction:: N/A
Small clusters prediction:: N/A
Single AA prediction:: N/A

Stachelhaus prediction details:

Stachelhaus sequence:: DpfSiGMIiK
Nearest Stachelhaus code:: thr
Stachelhaus code match:: 60% (weak)

SLUG_08120

Search NORINE for peptide: strict or relaxed

AMP-binding (271..643): val

NRPSPredictor2: val

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic
Large clusters prediction:: gly, ala, val, leu, ile, abu, iva
Small clusters prediction:: val, leu, ile, abu, iva
Single AA prediction:: N/A

Stachelhaus prediction details:

Stachelhaus sequence:: DAfLIGAVmK
Nearest Stachelhaus code:: val
Stachelhaus code match:: 80% (moderate)

SLUG_08130

Search NORINE for peptide: strict or relaxed

AMP-binding (439..831): val

NRPSPredictor2: val

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic
Large clusters prediction:: gly, ala, val, leu, ile, abu, iva
Small clusters prediction:: val, leu, ile, abu, iva
Single AA prediction:: val

Stachelhaus prediction details:

Stachelhaus sequence:: DAFWfGGTFK
Nearest Stachelhaus code:: val
Stachelhaus code match:: 90% (moderate)

SLUG_08150

Search NORINE for peptide: strict or relaxed

AMP-binding (31..404): cys

NRPSPredictor2: cys

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic
Large clusters prediction:: cys
Small clusters prediction:: cys
Single AA prediction:: cys

Stachelhaus prediction details:

Stachelhaus sequence:: DLFNLSLIWK
Nearest Stachelhaus code:: cys
Stachelhaus code match:: 100% (strong)