BGC0001415 - 1 region(s) - antiSMASH results

Identified secondary metabolite regions using strictness 'relaxed'

BGC0001415 (Serratia marcescens subsp. marcescens Db11)

Region	Type	From	To	Most similar known cluster		Similarity
Region 1	NRPS,T1PKS	1	30,288	althiomycin	NRP + Polyketide:Modular type I	66%

BGC0001415 - Region 1 - NRPS,T1PKS

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Location: 1 - 30,288 nt. (total: 30,288 nt) Show pHMM detection rules used

Region on contig edge.

NRPS: cds(Condensation and (AMP-binding or A-OX))
T1PKS: cds(PKS_AT and (PKS_KS or ene_KS or mod_KS or hyb_KS or itr_KS or tra_KS))

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core biosynthetic genes

additional biosynthetic genes

transport-related genes

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Gene details

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MIBiG

NRPS/PKS domains

MIBiG comparison

KnownClusterBlast

NRPS/PKS modules

External annotation

Name		MIBiG
Version		3.0

Type		Subregion
Location		1 - 30,289
Label		BGC0001415

Detailed domain annotation

Selected features only

Show module domains

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001415.1	2.00	NRP	althiomycin	Serratia marcescens subsp. marcescens Db11
BGC0000955.1	0.73	NRP, Polyketide	althiomycin	Myxococcus xanthus
BGC0002071.1	0.64	NRP	Virginiafactin	Pseudomonas sp. QS1027
BGC0000308.1	0.53	NRP	aureusimine	Staphylococcus aureus subsp. aureus str. JKD6008
BGC0001132.1	0.52	NRP	xenotetrapeptide	Xenorhabdus nematophila ATCC 19061
BGC0001479.1	0.52	NRP	anabaenopeptin NZ857, nostamide A	Nostoc punctiforme PCC 73102
BGC0001878.1	0.51	NRP, Polyketide	detoxin N2, detoxin N3	Streptomyces sp. NRRL B-1347
BGC0001560.1	0.51	NRP, Polyketide	cryptomaldamide	Moorea producens JHB
BGC0000355.1	0.50	NRP	fumiquinazoline A, fumiquinazoline C, fumiquinazoline D	Aspergillus fumigatus Af293
BGC0001128.1	0.50	NRP	luminmide	Photorhabdus laumondii subsp. laumondii TTO1

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001415.1	1.00	NRP	althiomycin	Serratia marcescens subsp. marcescens Db11
BGC0000955.1	0.69	NRP, Polyketide	althiomycin	Myxococcus xanthus
BGC0002071.1	0.65	NRP	Virginiafactin	Pseudomonas sp. QS1027
BGC0000308.1	0.60	NRP	aureusimine	Staphylococcus aureus subsp. aureus str. JKD6008
BGC0001132.1	0.60	NRP	xenotetrapeptide	Xenorhabdus nematophila ATCC 19061
BGC0001479.1	0.59	NRP	anabaenopeptin NZ857, nostamide A	Nostoc punctiforme PCC 73102
BGC0001878.1	0.59	NRP, Polyketide	detoxin N2, detoxin N3	Streptomyces sp. NRRL B-1347
BGC0001560.1	0.59	NRP, Polyketide	cryptomaldamide	Moorea producens JHB
BGC0000355.1	0.59	NRP	fumiquinazoline A, fumiquinazoline C, fumiquinazoline D	Aspergillus fumigatus Af293
BGC0001128.1	0.58	NRP	luminmide	Photorhabdus laumondii subsp. laumondii TTO1

Similar known gene clusters

Module view

Legend

NRPS/PKS products

NRPS/PKS monomers

Predicted core structure(s)

For candidate cluster 1, location 0 - 30288:

Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:: (gly - cys) + (D-ser - D-cys - gly - mal)

Direct lookup in NORINE database: strict or relaxed

Link to NORINE database query form

NRPS/PKS monomer predictions

SMDB11_2289

Search NORINE for peptide: strict or relaxed

AMP-binding (524..938): ser

NRPSPredictor2: ser

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic
Large clusters prediction:: ser, thr, dhpg, hpg
Small clusters prediction:: ser
Single AA prediction:: ser

Stachelhaus prediction details:

Stachelhaus sequence:: DVWHFSLIDK
Nearest Stachelhaus code:: ser
Stachelhaus code match:: 100% (strong)

AMP-binding (2041..2441): cys

NRPSPredictor2: cys

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic
Large clusters prediction:: cys
Small clusters prediction:: cys
Single AA prediction:: cys

Stachelhaus prediction details:

Stachelhaus sequence:: DLYNLSLIWK
Nearest Stachelhaus code:: cys
Stachelhaus code match:: 100% (strong)

AMP-binding (3535..3913): gly

NRPSPredictor2: gly

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic
Large clusters prediction:: gly, ala, val, leu, ile, abu, iva
Small clusters prediction:: gly, ala
Single AA prediction:: gly

Stachelhaus prediction details:

Stachelhaus sequence:: DILQLGVIWK
Nearest Stachelhaus code:: gly
Stachelhaus code match:: 100% (strong)

PKS_AT (4630..4922): mal

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 87.5%; inactive: 83.3%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 152.7
inactive: 104.2
Methoxymalonyl-CoA: 61.4
Methylmalonyl-CoA: 56.7
Propionyl-CoA: 49.9
2-Methylbutyryl-CoA: 26.4
Ethylmalonyl-CoA: 24.2
Isobutyryl-CoA: 23.7
CHC-CoA: 16.6
Benzoyl-CoA: 12.1
trans-1,2-CPDA: 9.6
fatty_acid: 0.0
Acetyl-CoA: 0.0
3-Methylbutyryl-CoA: 0.0

SMDB11_2290

Search NORINE for peptide: strict or relaxed

AMP-binding (378..780): gly

NRPSPredictor2: gly

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic
Large clusters prediction:: gly, ala, val, leu, ile, abu, iva
Small clusters prediction:: gly, ala
Single AA prediction:: gly

Stachelhaus prediction details:

Stachelhaus sequence:: DILQLGVvWK
Nearest Stachelhaus code:: gly
Stachelhaus code match:: 90% (moderate)

AMP-binding (1445..1848): cys

NRPSPredictor2: cys

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic
Large clusters prediction:: cys
Small clusters prediction:: cys
Single AA prediction:: cys

Stachelhaus prediction details:

Stachelhaus sequence:: DLYNLSLIWK
Nearest Stachelhaus code:: cys
Stachelhaus code match:: 100% (strong)