BGC0001695 - 1 region(s) - antiSMASH results

Identified secondary metabolite regions using strictness 'relaxed'

BGC0001695 (Streptomyces conglobatus)

Region	Type	From	To	Most similar known cluster		Similarity
Region 1	NRPS,T1PKS	1	41,200	neoantimycin	NRP + Polyketide	85%

BGC0001695 - Region 1 - NRPS,T1PKS

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Location: 1 - 41,200 nt. (total: 41,200 nt) Show pHMM detection rules used

Region on contig edge.

NRPS: cds(Condensation and (AMP-binding or A-OX))
T1PKS: cds(PKS_AT and (PKS_KS or ene_KS or mod_KS or hyb_KS or itr_KS or tra_KS))

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core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

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resistance

TTA codons

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Gene details

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MIBiG

NRPS/PKS domains

MIBiG comparison

KnownClusterBlast

NRPS/PKS modules

External annotation

Name		MIBiG
Version		3.0

Type		Subregion
Location		1 - 41,201
Label		BGC0001695

Detailed domain annotation

Selected features only

Show module domains

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001695.1	1.59	NRP	neoantimycin	Streptomyces conglobatus
BGC0001919.1	0.89	NRP, Polyketide	neoantimycin	Streptomyces orinoci
BGC0001918.1	0.81	NRP, Polyketide	JBIR-06	Streptomyces sp.
BGC0001909.1	0.63	Polyketide	strobilurin	Strobilurus tenacellus
BGC0002058.1	0.63	Other	Reutericyclin A, Reutericyclin B, Reutericyclin C, Reutericyclin D	Streptococcus mutans B04Sm5
BGC0001023.1	0.60	NRP, Polyketide	myxochromide S1	Stigmatella aurantiaca
BGC0001455.1	0.59	NRP, Polyketide	antimycin	Streptomyces argillaceus
BGC0000958.1	0.59	NRP, Polyketide	antimycin	Streptomyces sp. S4
BGC0001216.1	0.57	NRP, Polyketide	splenocin	Streptomyces sp. CNQ431
BGC0001878.1	0.53	NRP, Polyketide	detoxin N2, detoxin N3	Streptomyces sp. NRRL B-1347

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001695.1	0.93	NRP	neoantimycin	Streptomyces conglobatus
BGC0001919.1	0.75	NRP, Polyketide	neoantimycin	Streptomyces orinoci
BGC0001918.1	0.72	NRP, Polyketide	JBIR-06	Streptomyces sp.
BGC0001909.1	0.65	Polyketide	strobilurin	Strobilurus tenacellus
BGC0002058.1	0.65	Other	Reutericyclin A, Reutericyclin B, Reutericyclin C, Reutericyclin D	Streptococcus mutans B04Sm5
BGC0001023.1	0.64	NRP, Polyketide	myxochromide S1	Stigmatella aurantiaca
BGC0001455.1	0.63	NRP, Polyketide	antimycin	Streptomyces argillaceus
BGC0000958.1	0.63	NRP, Polyketide	antimycin	Streptomyces sp. S4
BGC0001216.1	0.62	NRP, Polyketide	splenocin	Streptomyces sp. CNQ431
BGC0001878.1	0.60	NRP, Polyketide	detoxin N2, detoxin N3	Streptomyces sp. NRRL B-1347

Similar known gene clusters

Module view

Legend

NRPS/PKS products

NRPS/PKS monomers

Predicted core structure(s)

For candidate cluster 1, location 0 - 41200:

Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:: (thr) + (Me-mal)

Direct lookup in NORINE database: strict or relaxed

Link to NORINE database query form

NRPS/PKS monomer predictions

natB

Search NORINE for peptide: strict or relaxed

AMP-binding (473..887): thr

NRPSPredictor2: thr

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic
Large clusters prediction:: ser, thr, dhpg, hpg
Small clusters prediction:: thr
Single AA prediction:: thr

Stachelhaus prediction details:

Stachelhaus sequence:: DFWNVGMVHK
Nearest Stachelhaus code:: thr
Stachelhaus code match:: 100% (strong)

CAL_domain (1750..2164): pk

minowa: fatty_acid

Prediction, score:

fatty_acid: 20.0
Acetyl-CoA: 7.6
AHBA: 0.1
shikimic_acid: 0.0
NH2: -0.7

CAL_domain (3668..3964): pk

minowa: NH2

Prediction, score:

NH2: 31.0
shikimic_acid: 0.0
fatty_acid: 0.0
Acetyl-CoA: 0.0
AHBA: 0.0

natC

PKS_AT (543..820): mal

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 62.5%; 2-Rhyd-Malonyl-CoA: 54.2%; inactive: 54.2%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 117.5
inactive: 71.8
Methoxymalonyl-CoA: 58.9
Methylmalonyl-CoA: 45.3
Propionyl-CoA: 31.3
Ethylmalonyl-CoA: 30.5
Isobutyryl-CoA: 29.1
Benzoyl-CoA: 21.9
2-Methylbutyryl-CoA: 12.0
fatty_acid: 10.2
trans-1,2-CPDA: 0.0
CHC-CoA: 0.0
Acetyl-CoA: 0.0
3-Methylbutyryl-CoA: 0.0

natD

CAL_domain (1056..1473): pk

minowa: fatty_acid

Prediction, score:

fatty_acid: 13.0
NH2: 2.4
shikimic_acid: 0.0
Acetyl-CoA: 0.0
AHBA: 0.0

natF

Search NORINE for peptide: strict or relaxed

AMP-binding (7..405): X

NRPSPredictor2: (unknown)

SVM prediction details:

NOTE: outside applicability domain

Predicted physicochemical class:: hydrophobic-aliphatic
Large clusters prediction:: N/A
Small clusters prediction:: N/A
Single AA prediction:: N/A

Stachelhaus prediction details:

Stachelhaus sequence:: hGvwLGVVgK
Nearest Stachelhaus code:: ile
Stachelhaus code match:: 60% (weak)