BGC0001707 - 1 region(s) - antiSMASH results

Identified secondary metabolite regions using strictness 'relaxed'

BGC0001707 (Streptomyces sp)

Region	Type	From	To	Most similar known cluster		Similarity
Region 1	thiopeptide	1	27,246	nosiheptide	RiPP:Thiopeptide	53%

BGC0001707 - Region 1 - thiopeptide

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Location: 1 - 27,246 nt. (total: 27,246 nt) Show pHMM detection rules used

Region on contig edge.

thiopeptide: ((YcaO or TIGR03604) and ((thio_amide and (PF06968 or PF04055 or PF07366)) or Lant_dehydr_C or Lant_dehydr_N or PF07366 or PF06968 or PF04055) or thiostrepton)

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

TTA codons

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Gene details

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MIBiG

MIBiG comparison

KnownClusterBlast

Thiopeptides

External annotation

Name		MIBiG
Version		3.0

Type		Subregion
Location		1 - 27,247
Label		BGC0001707

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001707.1	1.00	RiPP	nosiheptide	Streptomyces sp.
BGC0000608.1	0.56	RiPP	nocathiacin	Actinokineospora fastidiosa
BGC0000610.1	0.32	RiPP	nosiheptide	Streptomyces actuosus
BGC0000628.1	0.28	RiPP	lactocillin	Lactobacillus paragasseri JV-V03
BGC0000631.1	0.23	Terpene	botrydial	Botrytis cinerea B05.10
BGC0001174.1	0.22	RiPP	corynazolicin	Corynebacterium urealyticum DSM 7111
BGC0000606.1	0.22	RiPP	lactazole	Streptomyces lactacystinaeus
BGC0001310.1	0.22	Terpene	naringenin	Streptomyces clavuligerus ATCC 27064
BGC0001146.1	0.22	RiPP	cyclothiazomycin C	Streptomyces sp. NRRL WC-3908
BGC0001224.1	0.21	Other	reductasporine	uncultured bacterium

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001707.1	1.00	RiPP	nosiheptide	Streptomyces sp.
BGC0000608.1	0.82	RiPP	nocathiacin	Actinokineospora fastidiosa
BGC0000610.1	0.66	RiPP	nosiheptide	Streptomyces actuosus
BGC0000628.1	0.61	RiPP	lactocillin	Lactobacillus paragasseri JV-V03
BGC0000631.1	0.56	Terpene	botrydial	Botrytis cinerea B05.10
BGC0001174.1	0.56	RiPP	corynazolicin	Corynebacterium urealyticum DSM 7111
BGC0000606.1	0.55	RiPP	lactazole	Streptomyces lactacystinaeus
BGC0001310.1	0.55	Terpene	naringenin	Streptomyces clavuligerus ATCC 27064
BGC0001146.1	0.55	RiPP	cyclothiazomycin C	Streptomyces sp. NRRL WC-3908
BGC0001224.1	0.53	Other	reductasporine	uncultured bacterium

Similar known gene clusters

Thiopeptide predictions

Thiopeptide(s)

AQM75228.1

Leader:

MDAELNGLDIDALEISEFLDENRLEDSEVVAKVMSA

Core:

SCTTCECCCSCSS

Core with dehydrations:

DhaCysDhbDhbCysECysCysCysDhaCysDhaDha

Legend:

Dha: Didehydroalanine
Dhb: Didehydrobutyrine

Types:

Type I: Featuring genes encoding indolic acid side ring (series e)
Type II: Featuring the gene coding for quinaldic acid moiety formation (series a, b, and c)
Type III: No genes for synthesizing L-Trp derivatives (series d)

Thiopeptides

Core peptide predictions

AQM75228.1

Putative Type I

Cleavage pHMM score: 10.70

RODEO score: 31

Monoisotopic mass: 1315.3 Da

Molecular weight: 1316.5 Da

Predicted peptide features:
Central ring: pyridine tetrasubstituted (hydroxyl group present); second macrocycle

Macrocycle: 26-member

Tail reaction: dealkylation of C-Terminal residue; amidation

Considering maturation reactions

Monoisotopic mass: 1221.2 Da

Molecular weight: 1222.4 Da

Alternative weights: (assuming N unmodified Ser/Thr residues); 1334.5 Da N = 1; 1352.5 Da N = 2; 1370.6 Da N = 3; 1388.6 Da N = 4; 1406.6 Da N = 5; 1424.6 Da N = 6