BGC0000552 - 1 region(s) - antiSMASH results

Identified secondary metabolite regions using strictness 'relaxed'

BGC0000552 (Streptococcus mutans)

Region	Type	From	To	Most similar known cluster		Similarity
Region 1	lanthipeptide-class-ii	1	11,776	BHT-Aα / BHT-Aβ	RiPP:Lanthipeptide	87%

BGC0000552 - Region 1 - lanthipeptide-class-ii

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Location: 1 - 11,776 nt. (total: 11,776 nt) Show pHMM detection rules used

Region on contig edge.

lanthipeptide-class-ii: cds(LANC_like and DUF4135)

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

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Gene details

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MIBiG

MIBiG comparison

KnownClusterBlast

Lanthipeptides

External annotation

Name		MIBiG
Version		3.0

Type		Subregion
Location		1 - 11,777
Label		BGC0000552

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000552.1	1.00	RiPP	SmbA, SmbB	Streptococcus mutans
BGC0000497.1	0.65	RiPP	BHT-Aα, BHT-Aβ	Streptococcus ratti
BGC0001229.1	0.32	RiPP	SBI-06990 A1, SBI-06989 A2	Streptomyces bingchenggensis BCW-1
BGC0001579.1	0.31	RiPP	duramycin	Streptomyces cinnamoneus
BGC0000525.1	0.31	RiPP	lichenicidin VK21 A1, lichenicidin VK21 A2	Bacillus licheniformis
BGC0000554.1	0.31	RiPP	SRO15-3108	Streptomyces filamentosus NRRL 15998
BGC0000539.1	0.29	RiPP	nukacin ISK-1	Staphylococcus warneri
BGC0000504.1	0.27	RiPP	cytolysin ClyLl, cytolysin ClyLs	Plasmid pAD1
BGC0000500.1	0.27	RiPP	carnolysin A1, carnolysin A2	Carnobacterium maltaromaticum
BGC0000528.1	0.23	RiPP	michiganin A	Clavibacter michiganensis subsp. michiganensis NCPPB 382

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000552.1	1.00	RiPP	SmbA, SmbB	Streptococcus mutans
BGC0000497.1	0.87	RiPP	BHT-Aα, BHT-Aβ	Streptococcus ratti
BGC0001229.1	0.65	RiPP	SBI-06990 A1, SBI-06989 A2	Streptomyces bingchenggensis BCW-1
BGC0001579.1	0.64	RiPP	duramycin	Streptomyces cinnamoneus
BGC0000525.1	0.64	RiPP	lichenicidin VK21 A1, lichenicidin VK21 A2	Bacillus licheniformis
BGC0000554.1	0.64	RiPP	SRO15-3108	Streptomyces filamentosus NRRL 15998
BGC0000539.1	0.62	RiPP	nukacin ISK-1	Staphylococcus warneri
BGC0000504.1	0.61	RiPP	cytolysin ClyLl, cytolysin ClyLs	Plasmid pAD1
BGC0000500.1	0.61	RiPP	carnolysin A1, carnolysin A2	Carnobacterium maltaromaticum
BGC0000528.1	0.57	RiPP	michiganin A	Clavibacter michiganensis subsp. michiganensis NCPPB 382

Similar known gene clusters

Lanthipeptide predictions

Lanthipeptide(s) for smbM1

smbA

Leader:

MKSNLLKINNVTEMEKNMVTLIKDEDMLAG

Core:

GSTPACAIGVVGITVAVTGISTACTSRCINK

Core with dehydrations:

GDhaDhbPACysAIGVVGIDhbVAVDhbGIDhaDhbACysDhbDhaRCysINK

smbB

Leader:

MKEIQKAGLQEELSILMDDANNLEQLTAG

Core:

IGTTVVNSTFSIVLGNKGYICTVTVECMRNCSK

Core with dehydrations:

IGDhbDhbVVNDhaDhbFDhaIVLGNKGYICysDhbVDhbVECysMRNCysDhaK

Lanthipeptide(s) for smbM2

smbA

Leader:

MKSNLLKINNVTEMEKNMVTLIKDEDMLAG

Core:

GSTPACAIGVVGITVAVTGISTACTSRCINK

Core with dehydrations:

GDhaDhbPACysAIGVVGIDhbVAVDhbGIDhaDhbACysDhbDhaRCysINK

smbB

Leader:

MKEIQKAGLQEELSILMDDANNLEQLTAG

Core:

IGTTVVNSTFSIVLGNKGYICTVTVECMRNCSK

Core with dehydrations:

IGDhbDhbVVNDhaDhbFDhaIVLGNKGYICysDhbVDhbVECysMRNCysDhaK

Legend:

Dha: Didehydroalanine
Dhb: Didehydrobutyrine

Lanthipeptides

Core peptide predictions

smbA - Class II

Cleavage pHMM score: -1.70

RODEO score: 0

Monoisotopic mass: 2805.5 Da

Molecular weight: 2807.3 Da

Number of bridges: 3

Alternative weights: (assuming N unmodified Ser/Thr residues); 2825.3 Da N = 1; 2843.3 Da N = 2; 2861.3 Da N = 3; 2879.4 Da N = 4; 2897.4 Da N = 5

smbB - Class II

Cleavage pHMM score: -3.00

RODEO score: 0

Monoisotopic mass: 3392.7 Da

Molecular weight: 3395.0 Da

Number of bridges: 3

Alternative weights: (assuming N unmodified Ser/Thr residues); 3413.0 Da N = 1; 3431.0 Da N = 2; 3449.0 Da N = 3; 3467.0 Da N = 4; 3485.1 Da N = 5

smbA - Class II

Cleavage pHMM score: -1.70

RODEO score: 0

Monoisotopic mass: 2805.5 Da

Molecular weight: 2807.3 Da

Number of bridges: 3

Alternative weights: (assuming N unmodified Ser/Thr residues); 2825.3 Da N = 1; 2843.3 Da N = 2; 2861.3 Da N = 3; 2879.4 Da N = 4; 2897.4 Da N = 5

smbB - Class II

Cleavage pHMM score: -3.00

RODEO score: 0

Monoisotopic mass: 3392.7 Da

Molecular weight: 3395.0 Da

Number of bridges: 3

Alternative weights: (assuming N unmodified Ser/Thr residues); 3413.0 Da N = 1; 3431.0 Da N = 2; 3449.0 Da N = 3; 3467.0 Da N = 4; 3485.1 Da N = 5