BGC0001058 - 1 region(s) - antiSMASH results

Identified secondary metabolite regions using strictness 'relaxed'

BGC0001058 (Streptomyces pilosus)

Region	Type	From	To	Most similar known cluster		Similarity
Region 1	NRPS,NRPS-like	1	84,773	bleomycin	NRP:Glycopeptide + Polyketide:Modular type I + Saccharide:Hybrid/tailoring	46%

BGC0001058 - Region 1 - NRPS,NRPS-like

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Location: 1 - 84,773 nt. (total: 84,773 nt) Show pHMM detection rules used

Region on contig edge.

NRPS: cds(Condensation and (AMP-binding or A-OX))
NRPS-like: cds((PP-binding or NAD_binding_4) and (AMP-binding or A-OX))

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core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

TTA codons

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Gene details

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MIBiG

NRPS/PKS domains

MIBiG comparison

KnownClusterBlast

NRPS/PKS modules

External annotation

Name		MIBiG
Version		3.0

Type		Subregion
Location		1 - 84,774
Label		BGC0001058

Detailed domain annotation

Selected features only

Show module domains

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001058.1	2.18	NRP, Polyketide, Saccharide	zorbamycin	Streptomyces flavoviridis
BGC0000427.1	1.33	NRP	shinorine, 4-deoxygadusol, mycosporine glycine	Trichormus variabilis ATCC 29413
BGC0000375.1	1.30	NRP	indigoidine	Streptomyces chromofuscus
BGC0001249.1	1.29	NRP	dimethylcoprogen	Alternaria alternata
BGC0000457.1	1.27	NRP	vicibactin	Rhizobium etli CFN 42
BGC0000900.1	1.26	Other	ferrichrome	Aspergillus oryzae
BGC0000308.1	1.24	NRP	aureusimine	Staphylococcus aureus subsp. aureus str. JKD6008
BGC0001132.1	1.17	NRP	xenotetrapeptide	Xenorhabdus nematophila ATCC 19061
BGC0001261.1	1.16	NRP	AM-toxin	Alternaria alternata
BGC0001128.1	1.14	NRP	luminmide	Photorhabdus laumondii subsp. laumondii TTO1

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001058.1	0.98	NRP, Polyketide, Saccharide	zorbamycin	Streptomyces flavoviridis
BGC0001135.1	0.67	NRP	bicornutin A1, bicornutin A2	Xenorhabdus budapestensis
BGC0001758.1	0.67	NRP	rhizomide A, rhizomide B, rhizomide C	Paraburkholderia rhizoxinica HKI 454
BGC0000375.1	0.67	NRP	indigoidine	Streptomyces chromofuscus
BGC0000427.1	0.67	NRP	shinorine, 4-deoxygadusol, mycosporine glycine	Trichormus variabilis ATCC 29413
BGC0000457.1	0.66	NRP	vicibactin	Rhizobium etli CFN 42
BGC0000389.1	0.66	NRP	massetolide A	Pseudomonas fluorescens SS101
BGC0001561.1	0.66	NRP	curacomycin	Streptomyces curacoi
BGC0001844.1	0.66	NRP	holrhizin	Paraburkholderia rhizoxinica HKI 454
BGC0001249.1	0.66	NRP	dimethylcoprogen	Alternaria alternata

Similar known gene clusters

Module view

Legend

NRPS/PKS products

NRPS/PKS monomers

Predicted core structure(s)

For candidate cluster 1, location 33 - 84773:

Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:: (asn - X) + (ala) + (ser - asn) + (beta-ala - cys) + (X) + (val) + (X)

Direct lookup in NORINE database: strict or relaxed

For candidate cluster 2, location 33 - 72911:

Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:: (asn - X) + (ala) + (ser - asn) + (beta-ala - cys) + (X) + (val)

Direct lookup in NORINE database: strict or relaxed

For candidate cluster 3, location 52902 - >84771:

Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:: (beta-ala - cys) + (X) + (val) + (X)

Direct lookup in NORINE database: strict or relaxed

For candidate cluster 4, location 52902 - >84771:

Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:: (beta-ala - cys) + (X) + (val) + (X)

Direct lookup in NORINE database: strict or relaxed

For candidate cluster 5, location 60242 - 84773:

Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:: (val) + (X)

Direct lookup in NORINE database: strict or relaxed

Link to NORINE database query form

NRPS/PKS monomer predictions

zbmX

Search NORINE for peptide: strict or relaxed

AMP-binding (464..856): asn

NRPSPredictor2: asn

SVM prediction details:

Predicted physicochemical class:: hydrophilic
Large clusters prediction:: asp, asn, glu, gln, aad
Small clusters prediction:: asp, asn
Single AA prediction:: asn

Stachelhaus prediction details:

Stachelhaus sequence:: DfTKVGEVGK
Nearest Stachelhaus code:: asn
Stachelhaus code match:: 90% (moderate)

AMP-binding (1530..1931): X

NRPSPredictor2: (unknown)

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic
Large clusters prediction:: gly, ala, val, leu, ile, abu, iva
Small clusters prediction:: val, leu, ile, abu, iva
Single AA prediction:: N/A

Stachelhaus prediction details:

Stachelhaus sequence:: DSvLTAEVwK
Nearest Stachelhaus code:: his
Stachelhaus code match:: 80% (moderate)

zbmIX

Search NORINE for peptide: strict or relaxed

AMP-binding (480..880): ala

NRPSPredictor2: ala

SVM prediction details:

Predicted physicochemical class:: N/A
Large clusters prediction:: gly, ala, val, leu, ile, abu, iva
Small clusters prediction:: gly, ala
Single AA prediction:: ala

Stachelhaus prediction details:

Stachelhaus sequence:: DVFSnGLthK
Nearest Stachelhaus code:: d-lyserg
Stachelhaus code match:: 70% (weak)

zbmVI

Search NORINE for peptide: strict or relaxed

CAL_domain (42..469): pk

minowa: NH2

Prediction, score:

NH2: 260.9
fatty_acid: 16.8
Acetyl-CoA: 4.6
AHBA: 2.0
shikimic_acid: 0.0

AMP-binding (1151..1555): ser

NRPSPredictor2: ser

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic
Large clusters prediction:: ser, thr, dhpg, hpg
Small clusters prediction:: ser
Single AA prediction:: ser

Stachelhaus prediction details:

Stachelhaus sequence:: DVWHLSLIDK
Nearest Stachelhaus code:: ser
Stachelhaus code match:: 100% (strong)

AMP-binding (2198..2588): asn

NRPSPredictor2: asn

SVM prediction details:

Predicted physicochemical class:: hydrophilic
Large clusters prediction:: asp, asn, glu, gln, aad
Small clusters prediction:: asp, asn
Single AA prediction:: asn

Stachelhaus prediction details:

Stachelhaus sequence:: DLTKVGEVGK
Nearest Stachelhaus code:: asn
Stachelhaus code match:: 100% (strong)

zbmIV

Search NORINE for peptide: strict or relaxed

AMP-binding (499..904): beta-ala

NRPSPredictor2: beta-ala

SVM prediction details:

Predicted physicochemical class:: N/A
Large clusters prediction:: N/A
Small clusters prediction:: N/A
Single AA prediction:: N/A

Stachelhaus prediction details:

Stachelhaus sequence:: VDAlvSLADK
Nearest Stachelhaus code:: beta-ala
Stachelhaus code match:: 80% (moderate)

AMP-binding (1589..1994): cys

NRPSPredictor2: cys

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic
Large clusters prediction:: cys
Small clusters prediction:: cys
Single AA prediction:: cys

Stachelhaus prediction details:

Stachelhaus sequence:: DLYNLSmIWK
Nearest Stachelhaus code:: cys
Stachelhaus code match:: 90% (moderate)

zbmIII

Search NORINE for peptide: strict or relaxed

AMP-binding (39..394): X

NRPSPredictor2: (unknown)

SVM prediction details:

NOTE: outside applicability domain

Predicted physicochemical class:: hydrophobic-aliphatic
Large clusters prediction:: cys
Small clusters prediction:: cys
Single AA prediction:: cys

Stachelhaus prediction details:

Stachelhaus sequence:: erYsaSLIWK
Nearest Stachelhaus code:: cys
Stachelhaus code match:: 60% (weak)

zbmVIIb

Search NORINE for peptide: strict or relaxed

AMP-binding (13..403): val

NRPSPredictor2: val

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic
Large clusters prediction:: gly, ala, val, leu, ile, abu, iva
Small clusters prediction:: val, leu, ile, abu, iva
Single AA prediction:: val

Stachelhaus prediction details:

Stachelhaus sequence:: DAFWlGGTFK
Nearest Stachelhaus code:: val
Stachelhaus code match:: 90% (moderate)

ACG60755.1

Search NORINE for peptide: strict or relaxed

AMP-binding (13..416): X

NRPSPredictor2: (unknown)

SVM prediction details:

NOTE: outside applicability domain

Predicted physicochemical class:: hydrophobic-aliphatic
Large clusters prediction:: N/A
Small clusters prediction:: gly, ala
Single AA prediction:: ala

Stachelhaus prediction details:

Stachelhaus sequence:: gVyscSyfiK
Nearest Stachelhaus code:: ser
Stachelhaus code match:: 30% (weak)

ACG60761.1

Search NORINE for peptide: strict or relaxed

AMP-binding (550..936): X

NRPSPredictor2: val, leu, ile, abu, iva

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic
Large clusters prediction:: gly, ala, val, leu, ile, abu, iva
Small clusters prediction:: val, leu, ile, abu, iva
Single AA prediction:: N/A

Stachelhaus prediction details:

Stachelhaus sequence:: epLqVGAGwK
Nearest Stachelhaus code:: tcl
Stachelhaus code match:: 60% (weak)