BGC0001701 - 1 region(s) - antiSMASH results

Identified secondary metabolite regions using strictness 'relaxed'

BGC0001701 (Blautia obeum)

Region	Type	From	To	Most similar known cluster		Similarity
Region 1	lanthipeptide-class-i	1	16,220	ericin S	RiPP:Lanthipeptide	29%

BGC0001701 - Region 1 - lanthipeptide-class-i

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Location: 1 - 16,220 nt. (total: 16,220 nt) Show pHMM detection rules used

Region on contig edge.

lanthipeptide-class-i: ((LANC_like and (Lant_dehydr_N or Lant_dehydr_C)) and not (YcaO or TIGR03604))

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

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Gene details

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MIBiG

MIBiG comparison

KnownClusterBlast

Lanthipeptides

External annotation

Name		MIBiG
Version		3.0

Type		Subregion
Location		1 - 16,221
Label		BGC0001701

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001701.1	0.93	RiPP	nisin O	Blautia obeum
BGC0000544.1	0.32	RiPP	planosporicin	Planomonospora alba
BGC0000538.1	0.28	RiPP	nisin Z	Lactococcus lactis
BGC0000515.1	0.27	RiPP	geobacillin I	Geobacillus thermodenitrificans NG80-2
BGC0000528.1	0.27	RiPP	michiganin A	Clavibacter michiganensis subsp. michiganensis NCPPB 382
BGC0000540.1	0.26	RiPP	paenibacillin	Paenibacillus polymyxa OSY-DF
BGC0001289.1	0.26	RiPP	penisin	Paenibacillus ehimensis
BGC0000506.1	0.25	RiPP	entianin	Bacillus subtilis subsp. spizizenii
BGC0000503.1	0.25	RiPP	cinnamycin	Streptomyces cinnamoneus
BGC0001579.1	0.25	RiPP	duramycin	Streptomyces cinnamoneus

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001701.1	0.98	RiPP	nisin O	Blautia obeum
BGC0000544.1	0.65	RiPP	planosporicin	Planomonospora alba
BGC0000538.1	0.61	RiPP	nisin Z	Lactococcus lactis
BGC0000515.1	0.60	RiPP	geobacillin I	Geobacillus thermodenitrificans NG80-2
BGC0000528.1	0.60	RiPP	michiganin A	Clavibacter michiganensis subsp. michiganensis NCPPB 382
BGC0000540.1	0.60	RiPP	paenibacillin	Paenibacillus polymyxa OSY-DF
BGC0001289.1	0.59	RiPP	penisin	Paenibacillus ehimensis
BGC0000506.1	0.59	RiPP	entianin	Bacillus subtilis subsp. spizizenii
BGC0000503.1	0.59	RiPP	cinnamycin	Streptomyces cinnamoneus
BGC0001579.1	0.58	RiPP	duramycin	Streptomyces cinnamoneus

Similar known gene clusters

Lanthipeptide predictions

Lanthipeptide(s) for nsoB

nsoA1

Leader:

MGKFDDFDLDVTKTAAQGGIEPK

nsoA2

Leader:

MAKFDDFDLDVTKTAAQGGIEPK

nsoA3

Leader:

MAKFDDFDLDVTKTAAQGGIEPK

Shared core:

YKSKSACTPGCPTGILMTCPLKTATCGCHITGK

Core with dehydrations:

YKDhaKDhaACysDhbPGCysPDhbGILMDhbCysPLKDhbADhbCysGCysHIDhbGK

nsoA4

Leader:

MAKFDDFDLDIIEKKVRRDIIPA

Core:

SITSQHSFCTPNCLTGFLCPPKTQLTCTCKLKGQ

Core with dehydrations:

DhaIDhbDhaQHDhaFCysDhbPNCysLDhbGFLCysPPKDhbQLDhbCysDhbCysKLKGQ

Legend:

Dha: Didehydroalanine
Dhb: Didehydrobutyrine

Lanthipeptides

Core peptide predictions

nsoA1 - Class I

Cleavage pHMM score: 12.50

RODEO score: 26

Monoisotopic mass: 3226.6 Da

Molecular weight: 3228.9 Da

Number of bridges: 5

Alternative weights: (assuming N unmodified Ser/Thr residues); 3246.9 Da N = 1; 3264.9 Da N = 2; 3282.9 Da N = 3

nsoA2 - Class I

Cleavage pHMM score: 12.50

RODEO score: 26

Monoisotopic mass: 3226.6 Da

Molecular weight: 3228.9 Da

Number of bridges: 5

Alternative weights: (assuming N unmodified Ser/Thr residues); 3246.9 Da N = 1; 3264.9 Da N = 2; 3282.9 Da N = 3

nsoA3 - Class I

Cleavage pHMM score: 12.50

RODEO score: 26

Monoisotopic mass: 3226.6 Da

Molecular weight: 3228.9 Da

Number of bridges: 5

Alternative weights: (assuming N unmodified Ser/Thr residues); 3246.9 Da N = 1; 3264.9 Da N = 2; 3282.9 Da N = 3

nsoA4 - Class I

Cleavage pHMM score: 5.70

RODEO score: 24

Monoisotopic mass: 3522.8 Da

Molecular weight: 3525.1 Da

Number of bridges: 5

Alternative weights: (assuming N unmodified Ser/Thr residues); 3543.2 Da N = 1; 3561.2 Da N = 2; 3579.2 Da N = 3; 3597.2 Da N = 4