BGC0001569 - 1 region(s) - antiSMASH results

Identified secondary metabolite regions using strictness 'relaxed'

BGC0001569 (Streptomyces noursei ATCC 11455)

Region	Type	From	To	Most similar known cluster		Similarity
Region 1	NRPS,betalactone	1	46,257	ulleungmycin	NRP	63%

BGC0001569 - Region 1 - NRPS,betalactone

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Location: 1 - 46,257 nt. (total: 46,257 nt) Show pHMM detection rules used

Region on contig edge.

NRPS: cds(Condensation and (AMP-binding or A-OX))
betalactone: (HMGL-like and AMP-binding)

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core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

TTA codons

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Gene details

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MIBiG

NRPS/PKS domains

MIBiG comparison

KnownClusterBlast

NRPS/PKS modules

External annotation

Name		MIBiG
Version		3.0

Type		Subregion
Location		1 - 46,258
Label		BGC0001569

Detailed domain annotation

Selected features only

Show module domains

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001569.1	1.27	NRP	dechlorocuracomycin	Streptomyces noursei ATCC 11455
BGC0001562.1	0.80	NRP	curacomycin	Streptomyces curacoi
BGC0001814.1	0.78	NRP	ulleungmycin	Streptomyces sp. KCB13F003
BGC0001561.1	0.63	NRP	curacomycin	Streptomyces curacoi
BGC0000457.1	0.62	NRP	vicibactin	Rhizobium etli CFN 42
BGC0001132.1	0.55	NRP	xenotetrapeptide	Xenorhabdus nematophila ATCC 19061
BGC0000313.1	0.53	NRP	beauvericin	Beauveria bassiana
BGC0000389.1	0.53	NRP	massetolide A	Pseudomonas fluorescens SS101
BGC0001135.1	0.53	NRP	bicornutin A1, bicornutin A2	Xenorhabdus budapestensis
BGC0000342.1	0.53	NRP	enniatin	Fusarium equiseti

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001569.1	0.94	NRP	dechlorocuracomycin	Streptomyces noursei ATCC 11455
BGC0001814.1	0.78	NRP	ulleungmycin	Streptomyces sp. KCB13F003
BGC0001561.1	0.77	NRP	curacomycin	Streptomyces curacoi
BGC0001562.1	0.76	NRP	curacomycin	Streptomyces curacoi
BGC0000389.1	0.69	NRP	massetolide A	Pseudomonas fluorescens SS101
BGC0002071.1	0.68	NRP	Virginiafactin	Pseudomonas sp. QS1027
BGC0000426.1	0.67	NRP	sevadicin	Paenibacillus larvae
BGC0000457.1	0.66	NRP	vicibactin	Rhizobium etli CFN 42
BGC0001249.1	0.64	NRP	dimethylcoprogen	Alternaria alternata
BGC0000900.1	0.64	Other	ferrichrome	Aspergillus oryzae

Similar known gene clusters

Module view

Legend

NRPS/PKS products

NRPS/PKS monomers

Predicted core structure(s)

For candidate cluster 1, location 0 - 46257:

Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:: (X - D-val - D-X - val) + (X - D-asn)

Direct lookup in NORINE database: strict or relaxed

Link to NORINE database query form

NRPS/PKS monomer predictions

SNOUR_12640

Search NORINE for peptide: strict or relaxed

AMP-binding (518..929): X

NRPSPredictor2: ser, thr, dhpg, hpg

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic
Large clusters prediction:: ser, thr, dhpg, hpg
Small clusters prediction:: N/A
Single AA prediction:: N/A

Stachelhaus prediction details:

Stachelhaus sequence:: DtwDmGfVDK
Nearest Stachelhaus code:: gln
Stachelhaus code match:: 60% (weak)

AMP-binding (1599..2005): asn

NRPSPredictor2: asn

SVM prediction details:

Predicted physicochemical class:: hydrophilic
Large clusters prediction:: asp, asn, glu, gln, aad
Small clusters prediction:: asp, asn
Single AA prediction:: asn

Stachelhaus prediction details:

Stachelhaus sequence:: DLTKVGEVGK
Nearest Stachelhaus code:: asn
Stachelhaus code match:: 100% (strong)

SNOUR_12645

Search NORINE for peptide: strict or relaxed

AMP-binding (23..429): X

NRPSPredictor2: hydrophobic-aliphatic

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic
Large clusters prediction:: N/A
Small clusters prediction:: N/A
Single AA prediction:: N/A

Stachelhaus prediction details:

Stachelhaus sequence:: DVamaGAVtK
Nearest Stachelhaus code:: arg
Stachelhaus code match:: 60% (weak)

AMP-binding (1107..1506): val

NRPSPredictor2: val

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic
Large clusters prediction:: gly, ala, val, leu, ile, abu, iva
Small clusters prediction:: val, leu, ile, abu, iva
Single AA prediction:: val

Stachelhaus prediction details:

Stachelhaus sequence:: DAfWLGGTFK
Nearest Stachelhaus code:: val
Stachelhaus code match:: 90% (moderate)

AMP-binding (2620..3013): X

NRPSPredictor2: (unknown)

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic
Large clusters prediction:: N/A
Small clusters prediction:: N/A
Single AA prediction:: N/A

Stachelhaus prediction details:

Stachelhaus sequence:: DAImLGGiAK
Nearest Stachelhaus code:: leu
Stachelhaus code match:: 80% (moderate)

AMP-binding (4137..4542): val

NRPSPredictor2: val

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic
Large clusters prediction:: gly, ala, val, leu, ile, abu, iva
Small clusters prediction:: val, leu, ile, abu, iva
Single AA prediction:: N/A

Stachelhaus prediction details:

Stachelhaus sequence:: DALWmGGvFK
Nearest Stachelhaus code:: val
Stachelhaus code match:: 80% (moderate)