BGC0000520 - 1 region(s) - antiSMASH results

Identified secondary metabolite regions using strictness 'relaxed'

BGC0000520 (Lactococcus lactis)

Region	Type	From	To	Most similar known cluster		Similarity
Region 1	lanthipeptide-class-ii	1	9,481	staphylococcin C55 α / staphylococcin C55 β	RiPP:Lanthipeptide	30%

BGC0000520 - Region 1 - lanthipeptide-class-ii

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Location: 1 - 9,481 nt. (total: 9,481 nt) Show pHMM detection rules used

Region on contig edge.

lanthipeptide-class-ii: cds(LANC_like and DUF4135)

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

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Gene details

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MIBiG

MIBiG comparison

KnownClusterBlast

Lanthipeptides

External annotation

Name		MIBiG
Version		3.0

Type		Subregion
Location		1 - 9,482
Label		BGC0000520

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000520.1	0.45	RiPP	lacticin 3147 A1, lacticin 3147 A2	Lactococcus lactis
BGC0000555.1	0.36	RiPP	staphylococcin C55 α, staphylococcin C55 β	Staphylococcus aureus
BGC0000554.1	0.31	RiPP	SRO15-3108	Streptomyces filamentosus NRRL 15998
BGC0001391.1	0.30	RiPP	thusin	Bacillus thuringiensis serovar rongseni
BGC0001229.1	0.30	RiPP	SBI-06990 A1, SBI-06989 A2	Streptomyces bingchenggensis BCW-1
BGC0000504.1	0.28	RiPP	cytolysin ClyLl, cytolysin ClyLs	Plasmid pAD1
BGC0000500.1	0.27	RiPP	carnolysin A1, carnolysin A2	Carnobacterium maltaromaticum
BGC0000516.1	0.26	RiPP	geobacillin II	Geobacillus thermodenitrificans
BGC0001311.1	0.23	RiPP	flavecins	Ruminococcus flavefaciens FD-1
BGC0000552.1	0.23	RiPP	SmbA, SmbB	Streptococcus mutans

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000520.1	0.76	RiPP	lacticin 3147 A1, lacticin 3147 A2	Lactococcus lactis
BGC0000555.1	0.68	RiPP	staphylococcin C55 α, staphylococcin C55 β	Staphylococcus aureus
BGC0000554.1	0.64	RiPP	SRO15-3108	Streptomyces filamentosus NRRL 15998
BGC0001391.1	0.64	RiPP	thusin	Bacillus thuringiensis serovar rongseni
BGC0001229.1	0.63	RiPP	SBI-06990 A1, SBI-06989 A2	Streptomyces bingchenggensis BCW-1
BGC0000504.1	0.61	RiPP	cytolysin ClyLl, cytolysin ClyLs	Plasmid pAD1
BGC0000500.1	0.61	RiPP	carnolysin A1, carnolysin A2	Carnobacterium maltaromaticum
BGC0000516.1	0.59	RiPP	geobacillin II	Geobacillus thermodenitrificans
BGC0001311.1	0.57	RiPP	flavecins	Ruminococcus flavefaciens FD-1
BGC0000552.1	0.57	RiPP	SmbA, SmbB	Streptococcus mutans

Similar known gene clusters

Lanthipeptide predictions

Lanthipeptide(s) for ORF00037

ORF00035

Leader:

MNKNEIETQPVTWLEEVSDQNFDEDVFGA

Core:

CSTNTFSLSDYWGNNGAWCTLTHECMAWCK

Core with dehydrations:

CysDhaDhbNDhbFDhaLDhaDYWGNNGAWCysDhbLDhbHECysMAWCysK

ORF00036

Leader:

MKEKNMKKNDTIELQLGKYLEDDMIELAEGDESHGG

Core:

TTPATPAISILSAYISTNTCPTTKCTRAC

Core with dehydrations:

DhbDhbPADhbPAIDhaILDhaAYIDhaDhbNDhbCysPDhbDhbKCysDhbRACys

Lanthipeptide(s) for ORF00039

ORF00035

Leader:

MNKNEIETQPVTWLEEVSDQNFDEDVFGA

Core:

CSTNTFSLSDYWGNNGAWCTLTHECMAWCK

Core with dehydrations:

CysDhaDhbNDhbFDhaLDhaDYWGNNGAWCysDhbLDhbHECysMAWCysK

ORF00036

Leader:

MKEKNMKKNDTIELQLGKYLEDDMIELAEGDESHGG

Core:

TTPATPAISILSAYISTNTCPTTKCTRAC

Core with dehydrations:

DhbDhbPADhbPAIDhaILDhaAYIDhaDhbNDhbCysPDhbDhbKCysDhbRACys

Legend:

Dha: Didehydroalanine
Dhb: Didehydrobutyrine

Lanthipeptides

Core peptide predictions

ORF00035 - Class II

Cleavage pHMM score: 2.00

RODEO score: 0

Monoisotopic mass: 3302.4 Da

Molecular weight: 3304.7 Da

Number of bridges: 4

Alternative weights: (assuming N unmodified Ser/Thr residues); 3322.7 Da N = 1; 3340.7 Da N = 2; 3358.7 Da N = 3

ORF00036 - Class II

Cleavage pHMM score: 1.80

RODEO score: 0

Monoisotopic mass: 2787.5 Da

Molecular weight: 2789.2 Da

Number of bridges: 3

Alternative weights: (assuming N unmodified Ser/Thr residues); 2807.2 Da N = 1; 2825.2 Da N = 2; 2843.3 Da N = 3; 2861.3 Da N = 4; 2879.3 Da N = 5; 2897.3 Da N = 6; 2915.3 Da N = 7; 2933.4 Da N = 8

ORF00035 - Class II

Cleavage pHMM score: 2.00

RODEO score: 0

Monoisotopic mass: 3302.4 Da

Molecular weight: 3304.7 Da

Number of bridges: 4

Alternative weights: (assuming N unmodified Ser/Thr residues); 3322.7 Da N = 1; 3340.7 Da N = 2; 3358.7 Da N = 3

ORF00036 - Class II

Cleavage pHMM score: 1.80

RODEO score: 0

Monoisotopic mass: 2787.5 Da

Molecular weight: 2789.2 Da

Number of bridges: 3

Alternative weights: (assuming N unmodified Ser/Thr residues); 2807.2 Da N = 1; 2825.2 Da N = 2; 2843.3 Da N = 3; 2861.3 Da N = 4; 2879.3 Da N = 5; 2897.3 Da N = 6; 2915.3 Da N = 7; 2933.4 Da N = 8