BGC0001753 - 1 region(s) - antiSMASH results

Identified secondary metabolite regions using strictness 'relaxed'

BGC0001753 (Streptomyces globisporus subsp. globisporus)

Region	Type	From	To	Most similar known cluster		Similarity
Region 1	thiopeptide	1	20,652	berninamycin A	RiPP	46%

BGC0001753 - Region 1 - thiopeptide

Download region GenBank file

Download region SVG

Location: 1 - 20,652 nt. (total: 20,652 nt) Show pHMM detection rules used

Region on contig edge.

thiopeptide: ((YcaO or TIGR03604) and ((thio_amide and (PF06968 or PF04055 or PF07366)) or Lant_dehydr_C or Lant_dehydr_N or PF07366 or PF06968 or PF04055) or thiostrepton)

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

TTA codons

reset view

zoom to selection

Gene details

Select a gene to view the details available for it

MIBiG

MIBiG comparison

KnownClusterBlast

Thiopeptides

External annotation

Name		MIBiG
Version		3.0

Type		Subregion
Location		1 - 20,653
Label		BGC0001753

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001753.1	1.00	RiPP	radamycin, globimycin	Streptomyces globisporus subsp. globisporus
BGC0000607.1	0.31	RiPP	micrococcin P1	Macrococcus caseolyticus
BGC0000615.1	0.26	RiPP	TP-1161	Nocardiopsis sp. TFS65-07
BGC0001174.1	0.23	RiPP	corynazolicin	Corynebacterium urealyticum DSM 7111
BGC0002013.1	0.22	RiPP	curacozole	Streptomyces curacoi
BGC0001157.1	0.20	RiPP	bottromycin A2	Streptomyces scabiei 87.22
BGC0000468.1	0.20	RiPP	bottromycin A2	Streptomyces bottropensis
BGC0000606.1	0.20	RiPP	lactazole	Streptomyces lactacystinaeus
BGC0000470.1	0.19	RiPP	bottromycin D	Streptomyces sp. WMMB 272
BGC0001146.1	0.18	RiPP	cyclothiazomycin C	Streptomyces sp. NRRL WC-3908

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001753.1	1.00	RiPP	radamycin, globimycin	Streptomyces globisporus subsp. globisporus
BGC0000607.1	0.64	RiPP	micrococcin P1	Macrococcus caseolyticus
BGC0000615.1	0.59	RiPP	TP-1161	Nocardiopsis sp. TFS65-07
BGC0001174.1	0.56	RiPP	corynazolicin	Corynebacterium urealyticum DSM 7111
BGC0002013.1	0.55	RiPP	curacozole	Streptomyces curacoi
BGC0001157.1	0.53	RiPP	bottromycin A2	Streptomyces scabiei 87.22
BGC0000468.1	0.52	RiPP	bottromycin A2	Streptomyces bottropensis
BGC0000606.1	0.52	RiPP	lactazole	Streptomyces lactacystinaeus
BGC0000470.1	0.52	RiPP	bottromycin D	Streptomyces sp. WMMB 272
BGC0001146.1	0.50	RiPP	cyclothiazomycin C	Streptomyces sp. NRRL WC-3908

Similar known gene clusters

Thiopeptide predictions

Thiopeptide(s)

IF53_RS1000000135460

Leader:

MDAVESLDLNALEISDLIEDSNYSDETLSQAMAA

Core:

STTTTGCTTSSCSSSSS

Core with dehydrations:

DhaDhbDhbDhbDhbGCysDhbDhbDhaDhaCysDhaDhaDhaDhaDha

IF53_RS1000000135465

Leader:

MNSSEELDLNALEISDLIDELGRDNETLSQVMAA

Core:

SCVGTACACSSTSSSS

Core with dehydrations:

DhaCysVGDhbACysACysDhaDhaDhbDhaDhaDhaDha

Legend:

Dha: Didehydroalanine
Dhb: Didehydrobutyrine

Types:

Type I: Featuring genes encoding indolic acid side ring (series e)
Type II: Featuring the gene coding for quinaldic acid moiety formation (series a, b, and c)
Type III: No genes for synthesizing L-Trp derivatives (series d)

Thiopeptides

Core peptide predictions

IF53_RS1000000135460

Putative Type III

Cleavage pHMM score: 11.70

RODEO score: 33

Monoisotopic mass: 1583.6 Da

Molecular weight: 1584.6 Da

Predicted peptide features:
Central ring: pyridine trisubstituted

Macrocycle: 29-member

Tail reaction: dealkylation of C-Terminal residue; amidation

Alternative weights: (assuming N unmodified Ser/Thr residues); 1602.6 Da N = 1; 1620.6 Da N = 2; 1638.7 Da N = 3; 1656.7 Da N = 4; 1674.7 Da N = 5; 1692.7 Da N = 6; 1710.7 Da N = 7; 1728.8 Da N = 8; 1746.8 Da N = 9; 1764.8 Da N = 10; 1782.8 Da N = 11; 1800.8 Da N = 12; 1818.9 Da N = 13; 1836.9 Da N = 14

IF53_RS1000000135465

Putative Type III

Cleavage pHMM score: 21.40

RODEO score: 28

Monoisotopic mass: 1436.5 Da

Molecular weight: 1437.5 Da

Predicted peptide features:
Central ring: pyridine trisubstituted

Tail reaction: dealkylation of C-Terminal residue; amidation

Alternative weights: (assuming N unmodified Ser/Thr residues); 1455.6 Da N = 1; 1473.6 Da N = 2; 1491.6 Da N = 3; 1509.6 Da N = 4; 1527.6 Da N = 5; 1545.7 Da N = 6; 1563.7 Da N = 7; 1581.7 Da N = 8; 1599.7 Da N = 9