BGC0001669 - 1 region(s) - antiSMASH results

Identified secondary metabolite regions using strictness 'relaxed'

BGC0001669 (Microbacterium arborescens)

Region	Type	From	To	Most similar known cluster		Similarity
Region 1	lanthipeptide-class-ii,lipolanthine,furan	1	40,001	michiganin A	RiPP:Lanthipeptide	71%

BGC0001669 - Region 1 - furan,lanthipeptide-class-ii,lipolanthine

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Location: 1 - 40,001 nt. (total: 40,001 nt) Show pHMM detection rules used

Region on contig edge.

lanthipeptide-class-ii: cds(LANC_like and DUF4135)
lipolanthine: (micKC and Flavoprotein)
furan: (mmyO or AvrD)

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

TTA codons

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Gene details

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MIBiG

MIBiG comparison

KnownClusterBlast

Lanthipeptides

External annotation

Name		MIBiG
Version		3.0

Type		Subregion
Location		1 - 40,002
Label		BGC0001669

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001669.1	2.01	RiPP	microvionin	Microbacterium arborescens
BGC0000528.1	0.69	RiPP	michiganin A	Clavibacter michiganensis subsp. michiganensis NCPPB 382
BGC0000525.1	0.51	RiPP	lichenicidin VK21 A1, lichenicidin VK21 A2	Bacillus licheniformis
BGC0001576.1	0.50	RiPP	divamide A	Prochloron didemni
BGC0000554.1	0.47	RiPP	SRO15-3108	Streptomyces filamentosus NRRL 15998
BGC0001579.1	0.45	RiPP	duramycin	Streptomyces cinnamoneus
BGC0001660.1	0.41	RiPP	mathermycin	Marinactinospora thermotolerans
BGC0000503.1	0.41	RiPP	cinnamycin	Streptomyces cinnamoneus
BGC0001411.1	0.41	Saccharide	polysaccharide B	Bacteroides fragilis
BGC0001364.1	0.40	RiPP	cinnamycin B	Actinomadura atramentaria DSM 43919

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001669.1	1.00	RiPP	microvionin	Microbacterium arborescens
BGC0000528.1	0.74	RiPP	michiganin A	Clavibacter michiganensis subsp. michiganensis NCPPB 382
BGC0000527.1	0.65	RiPP	mersacidin	Bacillus sp. HIL-Y85/54728
BGC0000539.1	0.60	RiPP	nukacin ISK-1	Staphylococcus warneri
BGC0000525.1	0.59	RiPP	lichenicidin VK21 A1, lichenicidin VK21 A2	Bacillus licheniformis
BGC0000516.1	0.59	RiPP	geobacillin II	Geobacillus thermodenitrificans
BGC0000496.1	0.59	RiPP	AmfS	Streptomyces griseus subsp. griseus NBRC 13350
BGC0001787.1	0.59	RiPP	suicin 3908	Streptococcus suis
BGC0000626.1	0.59	RiPP	thuricin	Bacillus thuringiensis
BGC0001576.1	0.58	RiPP	divamide A	Prochloron didemni

Similar known gene clusters

Lanthipeptide predictions

Lanthipeptide(s) for lanM

lanA

Leader:

MITTHDQEMTIISPRWDMAARSTDGSTPSVQAQIDAEFERVVSPYM

Core:

ASSGWLCTLTIECGTLICACR

Core with dehydrations:

ADhaDhaGWLCysDhbLDhbIECysGDhbLICysACysR

micA

Leader:

MSLEQLEALDASSEAAEMAASLGS

Core:

QSC

Core with dehydrations:

QDhaCys

allorf_00522_00671

Leader:

VGLHRDGVREGA

Core:

DPLRDHGAVVDRRLHCGGGGERLRVRRDDPSLRRGRR

Core with dehydrations:

DPLRDHGAVVDRRLHCysGGGGERLRVRRDDPDhaLRRGRR

allorf_00702_00839

Leader:

LAERPALLRLPGA

Core:

QLARLASRCRRGRPRSRRARAHCRTRVLRRTA

Core with dehydrations:

QLARLADhaRCysRRGRPRDhaRRARAHCysRDhbRVLRRDhbA

allorf_00735_00812

Leader:

VSAGASRPGA

Core:

PASAPRCQPSELSTG

Core with dehydrations:

PADhaAPRCysQPDhaELDhaDhbG

allorf_01607_01678

Leader:

VGREQGTENDG

Core:

TAGVAERLCHRA

Core with dehydrations:

DhbAGVAERLCysHRA

allorf_01715_01864

Leader:

LEAALRSREQRAVGAPRRKVAGLRDDRRVRCPRIAGG

Core:

DGPRRRRRSGCP

Core with dehydrations:

DGPRRRRRDhaGCysP

allorf_04241_04405

Leader:

VRRAGCEDRRRRHRARRAVRCTRSRESDRSAHG

Core:

CPRAHRSRRPPRSVARSRGRA

Core with dehydrations:

CysPRAHRDhaRRPPRDhaVARDhaRGRA

allorf_12602_12805

Leader:

VSAPMPSSACAVRARTTSGTSMSMSPAM

Core:

RSSLSPGCRARASRRSRSARSSRRRSAGTSSPWLRTLGA

Core with dehydrations:

RDhaDhaLDhaPGCysRARADhaRRDhaRDhaARDhaDhaRRRDhaAGDhbDhaDhaPWLRDhbLGA

allorf_12839_13009

Leader:

VRRRRSPGA

Core:

SWRPRGRYRHARTASAASSTASSRCRRSSASWEHRGAAAERRPAGAP

Core with dehydrations:

DhaWRPRGRYRHARDhbADhaAADhaDhaDhbADhaDhaRCysRRDhaDhaADhaWEHRGAAAERRPAGAP

allorf_14922_15134

Leader:

VRMPSVRARARYRAVRLAGS

Core:

RATSIGVPATTMRPPALPPDGPRSITQSAEATTSMSCSTTTTVFPASTSA

Core with dehydrations:

RADhbDhaIGVPADhbDhbMRPPALPPDGPRDhaIDhbQDhaAEADhbDhbDhaMDhaCysDhaDhbDhbDhbDhbVFPADhaDhbDhaA

Legend:

Dha: Didehydroalanine
Dhb: Didehydrobutyrine

Lanthipeptides

Core peptide predictions

lanA - Class II

Cleavage pHMM score: -1.50

RODEO score: 0

Monoisotopic mass: 2064.0 Da

Molecular weight: 2065.5 Da

Number of bridges: 3

Additional modifications: AviCys

Alternative weights: (assuming N unmodified Ser/Thr residues); 2083.5 Da N = 1

micA - Class II

Cleavage pHMM score: -0.10

RODEO score: 0

Monoisotopic mass: 272.1 Da

Molecular weight: 272.3 Da

Number of bridges: 0

Additional modifications: AviCys

allorf_00522_00671 - Class II

Cleavage pHMM score: -4.80

RODEO score: 0

Monoisotopic mass: 4196.3 Da

Molecular weight: 4198.7 Da

Number of bridges: 0

Additional modifications: AviCys

allorf_00702_00839 - Class II

Cleavage pHMM score: -4.30

RODEO score: 0

Monoisotopic mass: 3724.2 Da

Molecular weight: 3726.4 Da

Number of bridges: 1

Additional modifications: AviCys

Alternative weights: (assuming N unmodified Ser/Thr residues); 3744.4 Da N = 1; 3762.5 Da N = 2

allorf_00735_00812 - Class II

Cleavage pHMM score: -7.10

RODEO score: 0

Monoisotopic mass: 1381.7 Da

Molecular weight: 1382.6 Da

Number of bridges: 0

Additional modifications: AviCys

Alternative weights: (assuming N unmodified Ser/Thr residues); 1400.6 Da N = 1; 1418.6 Da N = 2; 1436.6 Da N = 3

allorf_01607_01678 - Class II

Cleavage pHMM score: -7.10

RODEO score: 0

Monoisotopic mass: 1218.7 Da

Molecular weight: 1219.4 Da

Number of bridges: 0

Additional modifications: AviCys

allorf_01715_01864 - Class II

Cleavage pHMM score: -5.80

RODEO score: 0

Monoisotopic mass: 1347.7 Da

Molecular weight: 1348.6 Da

Number of bridges: 0

Additional modifications: AviCys

allorf_04241_04405 - Class II

Cleavage pHMM score: -5.90

RODEO score: 0

Monoisotopic mass: 2328.3 Da

Molecular weight: 2329.7 Da

Number of bridges: 0

Additional modifications: AviCys

Alternative weights: (assuming N unmodified Ser/Thr residues); 2347.7 Da N = 1; 2365.8 Da N = 2

allorf_12602_12805 - Class II

Cleavage pHMM score: -5.70

RODEO score: 0

Monoisotopic mass: 3963.3 Da

Molecular weight: 3965.5 Da

Number of bridges: 0

Additional modifications: AviCys

Alternative weights: (assuming N unmodified Ser/Thr residues); 3983.5 Da N = 1; 4001.5 Da N = 2; 4019.5 Da N = 3; 4037.5 Da N = 4; 4055.6 Da N = 5; 4073.6 Da N = 6; 4091.6 Da N = 7; 4109.6 Da N = 8; 4127.6 Da N = 9; 4145.7 Da N = 10; 4163.7 Da N = 11; 4181.7 Da N = 12

allorf_12839_13009 - Class II

Cleavage pHMM score: -2.00

RODEO score: 0

Monoisotopic mass: 4890.6 Da

Molecular weight: 4893.3 Da

Number of bridges: 0

Additional modifications: AviCys

Alternative weights: (assuming N unmodified Ser/Thr residues); 4911.4 Da N = 1; 4929.4 Da N = 2; 4947.4 Da N = 3; 4965.4 Da N = 4; 4983.4 Da N = 5; 5001.5 Da N = 6; 5019.5 Da N = 7; 5037.5 Da N = 8; 5055.5 Da N = 9; 5073.5 Da N = 10

allorf_14922_15134 - Class II

Cleavage pHMM score: -3.30

RODEO score: 0

Monoisotopic mass: 4618.4 Da

Molecular weight: 4621.2 Da

Number of bridges: 0

Additional modifications: AviCys

Alternative weights: (assuming N unmodified Ser/Thr residues); 4639.2 Da N = 1; 4657.2 Da N = 2; 4675.2 Da N = 3; 4693.3 Da N = 4; 4711.3 Da N = 5; 4729.3 Da N = 6; 4747.3 Da N = 7; 4765.3 Da N = 8; 4783.4 Da N = 9; 4801.4 Da N = 10; 4819.4 Da N = 11; 4837.4 Da N = 12; 4855.4 Da N = 13; 4873.5 Da N = 14; 4891.5 Da N = 15; 4909.5 Da N = 16; 4927.5 Da N = 17; 4945.5 Da N = 18